Mayo Clinic Program in Precision Genomics: Interventional Therapeutics

Why Mayo Clinic

Mayo Clinic is top‑ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

• Medical:
  Multiple plan options.
• Dental:
  Delta Dental or reimbursement account for flexible coverage.
• Vision:
  Affordable plan with national network.
• Pre‑Tax Savings: HSA and FSAs for eligible expenses.
• Retirement:
  Competitive retirement package to secure your future.

Mayo Clinic and its Department of Clinical Genomics, as well as other aligned Departments and Programs, are seeking exceptional physicians and scientists, experts in the rapidly evolving field of genome editing and therapeutic delivery, to drive innovation at the intersection of discovery, translational, clinical research, and clinical practice to join our new and rapidly evolving Program in Precision Genomics:
Interventional Therapeutics (PG‑IT).

The PG‑IT program at Mayo Clinic is a groundbreaking new initiative of highly innovative and creative scientists and physicians working collaboratively to advance next‑generation molecular therapies by delivering genetically targeted treatments in vivo. We are building an accomplished team of leaders including scientists driving innovation in genome editing and physicians who can deliver customized new and novel genetic therapies to the patients we serve.

• The Mayo Clinic Artificial Intelligence Program, driving the development of AI‑based drug discovery, predictive models, large language models, and AI agents within research and implemented into the Mayo Clinic clinical practice.
• Mayo Clinic Platform, the world’s largest distributed federated healthcare data network with cloud‑based storage of fully digitized longitudinal patient records and associated research data and biospecimens from >50M patients.
• Exceptional research and clinical programs, research infrastructure, shared research resources, and education and training programs to facilitate research in basic and clinical genomics and molecular engineering.
• A robust clinical research and clinical trials infrastructure that currently supports the delivery of the nation’s largest number of clinical trials to the patients we serve, including new and novel and “first in human” therapies, including cellular, biologic, and genetic therapies.
• Mayo Clinic’s unique collaborative ecosystem, which includes an integrated clinical practice, world‑class research platforms, and advanced infrastructure for gene and cell‑based therapeutic development.

Our goals for the PG‑IT program include in‑vivo human gene editing for rare and inherited genetic disorders and complex human diseases, the acceleration of drug repurposing for genetically targeted indications, and identifying the most promising novel gene‑editing interventions to benefit patients. These goals span therapeutic development, CRISPR‑ and RNA‑based interventions, genome engineering, molecular diagnostics, novel mechanisms and modes of delivery of genetic therapies in vivo, and the deployment of genomics‑enabled clinical care pathways for rare, inherited, and complex conditions.

Successful candidates will lead, design, and implement innovative genomic and translational approaches that improve patient outcomes while driving forward to the next generation of therapeutic and diagnostic discovery. Faculty will contribute to the development and integration of emerging genomic technologies into clinical and therapeutic pipelines, helping to shape programs that influence local, national, and global practice in genomic medicine.

The Department of Clinical Genomics at Mayo Clinic is a national leader in integrating advanced genomic science with patient‑centered clinical care. Our mission is to individualize…