Director Medical Operations

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Director of Medical Operations will play a key leadership role in driving planning and operations to ensure execution excellence across Medical Affairs. Key responsibilities for this individual will be to build and enable agile and nimble frameworks to drive processes that ensure seamless project execution: annual planning timeline and facilitation working with functional heads and GMAT partners, business processes relating to medical affairs contracting (e.g. SOWs, MSA’s), vendor oversight, budget/financial management, working with legal, procurement and finance partners.

This individual will also support medical affairs capabilities enhancement in systems and digital e.g.: internal websites with a goal to enhance team collaborations and operational efficiencies.

As a senior member of the Medical Operations function, the Director will serve as a central point of contact for internal efficiencies in the Medical Affairs department.

Medical Affairs Operations & Process Optimization – Drive continuous process improvement initiatives to enhance operational effectiveness and cross‑functional alignment.

Contracting & Vendor Oversight – Ensure compliance with internal policies, industry regulations, and legal requirements in all contracting activities; develop and maintain vendor relationships, oversee performance, deliverables, and risk mitigation strategies.

Budget & Financial Management – Develop and manage the Medical Affairs budget; partner with finance and procurement teams to optimize budget allocation; monitor spending trends.

Project & Operations Management – Oversee execution of Medical Affairs projects and initiatives; establish and manage project timelines, deliverables, and risk mitigation plans.

Digital & Systems Projects – Support digital transformation initiatives: implementation and optimization of medical systems, databases, reporting tools; identify and deploy technology solutions; ensure seamless integration of digital tools.

Medical Affairs Team Support – Provide strategic and operational support; assess, develop, and implement operations frameworks.

Cross‑Functional Collaboration & Compliance – Work closely with Legal, Compliance, Regulatory, and Finance teams; coordinate cross‑functional meetings, steering committees, and governance processes.

Congress Operations & External Engagements – Contribute to logistical planning and execution of medical congresses, advisory boards, symposia; ensure compliance and manage contracts.

The position responsibilities are not limited to the above and might change as the team’s needs evolve.

Minimum Bachelor's degree or Advanced degree (PhD, Pharm

D, MBA, MS, or relevant life sciences/business degree preferred).

15+ years of experience in biotechnology or pharmaceutical industry (with BS), 13+ years (with MS) or 11+ years (with Pharm

D/PhD); including 10+ years in Medical Affairs operations, project management, or a related function within biotech/pharma.

Proficient or expert in business planning, project management, and agile methodologies.

Expertise in contract management, vendor oversight, and budget/financial planning.

Strong leadership, strategic thinking, communication skills, and stakeholder orientation.

Ability to work in a fast‑paced, evolving environment while managing multiple priorities.

Knowledge of industry regulations (PhRMA Code, Sunshine Act, GPP, FDA, ACCME) and their impact on Medical Affairs operations.

Experience supporting Medical Affairs teams, systems, and processes to drive operational excellence.

Knowledge…