Associate Director, Biostatistics - Late Stage

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

This position serves as a study level statistician for oncology studies in clinical late-stage development and provides leadership across biostatistical activities. The Associate Director will collaborate across functions and contribute to program-level decision-making.

• Represent biostatistics on study and cross-functional project teams, providing statistical leadership.
• Lead and manage biostatistical activities to ensure consistency, scientific rigor, and timely deliverables.
• Provide statistical expertise for design, analysis, and reporting of clinical studies.
• Develop statistical analysis plans and analysis specifications; ensure analyses align with clinical and regulatory objectives.
• Collaborate with statistical programming to ensure that analysis is conducted per statistical plan and specifications and delivered with high quality.
• Collaborate with data management and clinical operations to ensure robust CRF and database development and quality data collection.
• Provide statistical input to the development of global health authority documents, regulatory interaction, and response to health authority submissions.
• Influence strategy and inform decision-making through data-driven insights and clear communication of risk and benefit.
• Collaborate in publications, assist in data interpretation, and ensure consistency and accuracy in data presentation.
• Contribute to the development of functional-level standards, SOPs, and templates.
• Keep abreast of new developments in statistics, drug development, and regulatory guidance and share knowledge with functional and cross-functional team members.

• Ph.D. or M.S. in Statistics/Biostatistics, a minimum of 5 years (for Ph.D.) and 8 years (for M.S.) of experience in biotech/pharma industry as a statistician. Level will be determined based on the relevance of experience.
• Hands‑on experience in design and analysis of late‑stage oncology trials is a must.
• Ability to work independently and within a team.
• Solid knowledge in ICH and other regulatory requirements related to biostatistical activities and clinical trials.
• Excellent verbal and written communication skills.
• Good interpersonal and project management skills.
• Proficiency in SAS and/or R.

• Hands‑on experience in design and analysis of phase 3 oncology trials is desirable.