Scientist​/Research Associate – AI Protein Design

Overview

Syst Immune is a leading and well-funded clinical-stage biopharmaceutical company with sites in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using established drug development platforms, focusing on bi-specific and multi-specific antibodies and antibody-drug conjugates (ADCs). Syst Immune has assets in various stages of clinical trials for solid tumor and hematologic indications and maintains a robust preclinical pipeline in discovery and IND-enabling stages.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

• Execute a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody-based elements via a data-driven approach.
• Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display-based protein discovery platforms.
• Design new macromolecular therapeutics using structural and sequence analysis, and employ in silico predictions to iteratively guide the lead development process.
• Analyze, interpret, document, and present data to the scientific and leadership teams.
• Collaborate with the Antibody Discovery, Protein Engineering, and Immuno-oncology teams to contribute to the company’s vision.

• PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field.
• 8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies.
• Experience with relevant macromolecular modeling software (e.g., Alpha Fold, RoseTTAFold, RF diffusion, Protein
  
  MPNN, Gromacs, MOE, Schrödinger).
• Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET).
• Proven contribution to therapeutic antibody development and selection is desirable; design and validation of novel biologically relevant antibodies are highly desirable.

The expected base salary range for this position is $80,000 - $180,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

Syst Immune is a leading and well-funded biotech company with a bright future. We offer a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match of up to 3%, and a five-year vesting schedule; 15 PTO days per year, sick leave, and 11 paid holidays.

Syst Immune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.