Sr. Scientist, Analytical R&D

Overview

Job Description The Materials and Biophysical Characterization group in Analytical Research and Development is seeking a highly self-motivated and innovative scientist with deep knowledge and strong problem-solving skills in biophysical characterization. The Biophysical Characterization team is responsible for building the mechanistic understanding of the interplay between formulation composition, process and stability of drug substance and drug product to ensure process robustness and product quality.

As a Senior Scientist, you will be supporting projects in the pipeline by developing and implementing biophysical and particle characterization assays collaborating with process, formulation and device as part of the CMC development team. You are expected to use your scientific expertise to find creative solutions to challenging problems which require deep analytical insight and critical thinking. Additional responsibilities include authoring technical reports and regulatory documents, presenting technical data, and project management.

You will conduct independent research, publish research findings, present at scientific conferences, and engage with various external scientific societies/organizations. This is an excellent growth and learning opportunity to work in an exciting, collaborative environment with a wide array of scientists from different divisions, and make significant contributions towards our life-saving medicines.

• Support projects in the pipeline by developing and implementing biophysical and particle characterization assays as part of the CMC development team.
• Collaborate with process, formulation and device teams.
• Author technical reports and regulatory documents; present technical data; manage projects.
• Conduct independent research, publish findings, present at scientific conferences, and engage with external scientific societies/organizations.
• Contribute to a collaborative environment with scientists from multiple divisions and contribute to the development of life-saving medicines.

• Ph.D. in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline with 0-4 years’ experience.
• MSc in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline with 4-8 years’ experience.

• Fundamental understanding of protein science, protein stability, and protein-protein interactions.
• Hands-on experience with biophysical and particle characterization techniques for biotherapeutics characterization; excellent analytical skills and ability to analyze and interpret complex data sets.
• Self-motivated with an outstanding scientific track record; track record of independent problem-solving applying deep technical and subject matter expertise.
• Excellent interpersonal and communication skills; actively engages in two-way communication to build trusting relationships.
• Excellent organizational skills to multi-task and manage multiple projects.
• Ability to drive operational excellence by clarifying and translating priorities into actionable steps, and ensure expectations are met aligned with agreed standards and methodologies.

• Experience with molecular modeling.
• Experience with cryo
  
  EM, BioNMR and/or Mass Spectrometry.
• Experience with biological formulation development and analytical method development.
• Experience with various modalities including peptides, mAbs, ADC, fusion protein.

• Accountability
• Adaptability
• Analytical Method Development
• Assay Development
• Bioanalytical Analysis
• Biochemical Assays
• Biomedical Engineering
• Biophysics
• Cell-Based Assays
• Chemical Biology
• Chemical Engineering
• Chemical Technology
• Communication
• GMP Environments
• Innovative Thinking
• Mass Spectrometry (MS)
• Molecular Modeling
• Nuclear Magnetic Resonance (NMR) Analysis
• Operational Excellence
• Process Analytical Technology (PAT)
• Project Management
• Protein Chemistry

• Current Employees apply here
• Current Contingent Workers apply here

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