Director, DMPK

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X Biosciences is an emerging computation powered small molecule drug discovery company based in Princeton, New Jersey. Quant

X aims to build a world class computational drug discovery platform by merging physics-based modeling and modern AI/machine technologies, while fully utilizing an industry-leading high-performance computing resource. With a team of highly accomplished drug hunters, empowered and tightly integrated by the platform, we strive to discover breakthrough medicines.

We are seeking a highly experienced expert in drug metabolism and pharmacokinetics (DMPK) to join our team with the following responsibilities:

• Serve as the resident subject matter expert for DMPK function at all stages of drug discovery and development
• Working collaboratively with project team members to design and execute the non-clinical DMPK strategy to address DMPK challenges
• Design and oversee DMPK studies at CRO partners, interpret data and provide timely feedback to project team members
• Create the DMPK package including human dose projection calculations to support nomination of preclinical candidates (PCC)
• Author and edit key preclinical and regulatory documents including study reports, investigator brochures, INDs and CTAs within agreed timelines.

• A PhD in Drug Metabolism, Pharmacokinetics or related discipline with a minimum of 12 years of biotech/pharmaceutical drug discovery and development experience
• Proven track record of supporting multiple research programs to advance high quality assets into the clinic
• Superior interpersonal and organizational skills with a demonstrated ability to think critically and strategically
• Experience working with contract research organizations (CRO) on program execution
• Excellent presentation and communication skills
• Experience with the drafting of regulatory submissions
• Relevant experience in business development for research or development assets

The above statements are intended to describe the general nature and level of work performed by individuals assigned to this position and are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required. All employees may be required to perform duties outside of their normal responsibilities from time to time, as needed.

The role is hybrid, reporting to Princeton, NJ HQ 2x/week. We offer a highly flexible work-life balance.

210,000 – 230,000/year with potential bonus eligibility. Salary offers are made based on the candidate’s qualifications, experience, skills, and education as they directly relate to the requirements of the position, budget for the position and cost of labor in the market in which the candidate will be hired.

• Medical/dental/vision coverage
• Hybrid working environment based at our headquarters in Princeton NJ, with free snacks and drinks
• 401(k) plan with employer match
• PTO and company-wide winter break
• Equity plan (if eligible)

• Ability to thrive in a start-up, fast-paced and dynamic environment with a lean team.
• Commitment to integrity, dependability, and ethical conduct; ability to handle confidential and proprietary information with the utmost discretion and sound judgment.
• Personal drive, energy and the ability to work effectively, with a strong sense of urgency, in a hands-on, action-oriented environment
• Strong leadership qualities that value and promote a culture of accountability—both for himself/herself and for others
• Demonstrated ability to work collaboratively and effectively with internal and external stakeholders

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X is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Please note:

we will neither consider unsolicited submissions for staffing firms not on our approved vendor list, nor do we offer sponsorship or C2C terms.