Associate Scientist - Throughput Purification

Associate Scientist – High Throughput Purification

Position: Associate Scientist – High Throughput Purification

Location: Spring House, PA (Fully onsite)

Compensation: $31.47/hr - $38.47/hr (dependent on skills, experience, education)

Benefits: 10 days PTO, 6 sick days, paid holidays, 401(k) with employer matching, medical, dental, and vision insurance (HSA, FSA, DCFSA options), paid sick leave and other paid time off as applicable by law.

Qualifications:

• Minimum bachelor’s degree in Analytical, Synthetic, Organic, Medicinal chemistry or related chemistry discipline.
• Minimum 2 years of analytical or purification experience with HPLC/SFC and mass spectrometry.
• Proficient with modern chromatography techniques including HPLC or SFC with MS detectors.
• Experience with Waters equipment and Masslynx software preferred.
• Independent thinker capable of effective collaboration in a highly matrixed environment.
• Detail-oriented with strong organizational and communication skills and good documentation practices.

Job Description:

We are seeking a highly motivated BS- or MS-level chemist with small molecule analytical and purification skills to work in our laboratories to advance drug discovery programs toward the clinic. The Associate Scientist will support purification operations in a high‑throughput discovery environment. This role is responsible for routine operation and maintenance of HPLC/MS and SFC/MS systems, performing small‑molecule and peptide purifications, and downstream sample handling including assay‑ready solution preparation, while ensuring safe, organized lab operations.

The ideal candidate is hands‑on, detail oriented, and experienced with chromatography and mass spectrometry workflows. She/he will maintain close interactions with scientists from Discovery Chemistry, Discovery Process Chemistry and Parallel Medicinal Chemistry teams to expedite compound design‑synthesis‑test iterations. Strong people skills and the ability to thrive in a team and goal‑driven environment are key attributes.

Responsibilities:

• Conduct daily system suitability checks on analytical and preparative HPLC/MS, SFC/MS.
• Perform preliminary method screening experiments, HPLC/MS and SFC/MS–based purifications of small molecules and peptides, post‑purification QC and downstream handling.
• Maintain instruments in good working condition; troubleshoot and perform maintenance as required; coordinate repairs and preventive maintenance with service provider when needed.
• Support lab operations and maintain general lab orderliness.
• Assist in the maintenance of a safe working environment and operate safely.
• Other duties and assignments as needed to support lab operations.

Seniority Level: Associate

Employment Type: Full‑time

Job Function: Science and Project Management;
Industries:
Biotechnology Research and Pharmaceutical Manufacturing