Distinguished Scientist, Translational Safety

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Discovery & Pre-Clinical/Clinical Development

Nonclinical Safety

Scientific/Technology

Cambridge, Massachusetts, United States of America;
San Diego, California, United States of America;
Spring House, Pennsylvania, United States of America

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

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We are searching for the best talent for a Distinguished Scientist, Translational Safety to be located in Spring House, PA or Cambridge, MA or San Diego, CA.

The Distinguished Scientist will serve as a key member of the Translational Safety team in Translational PK/PD & Investigative Toxicology (TPPIT) and Preclinical Sciences & Translational Safety (PSTS) and will be responsible for leading the predictive toxicology initiatives in the early drug discovery and de-risking. The successful candidate will work in matrixed teams evaluating, validating, recommending and integrating conventional in vitro models and complex cellular model systems for predicting off-target and major organ toxicities and guiding drug candidate selection during the early drug development process.

This scientist will work closely with teams across PSTS on mechanistic studies as needed while focusing on moving our predictive toxicity workflows to the next level. The Distinguished Scientist will be responsible for communicating predictive investigative screening plans and updates to PSTS issue teams, project teams, and global leadership in partnership with leaders in Translational Safety and in Therapeutic Development.

Strong knowledge of AI/ML model development is essential as we invest in an R&D wide digital transformation.

• Lead efforts to build and refine robust high-throughput in vitro organ specific cellular screening workflows
• Serve as the liaison between High throughput screening, Data Sciences, In Silico Modeling and Preclinical Safety Teams
• In collaboration with External Scientific Innovation and Business Development, evaluate external environment to identify new technologies, platforms & CROs with novel, cutting edge applications for in vitro toxicology
• Partner with members of Translation Safety & Discovery, Product Development and Supply (DPDS) functional groups to oversee the conversion of mechanistic cellular, molecular & biochemical toxicology assays into high throughput predictive screening assays
• Function as a key member of Global Translational Safety Team partnering with global leads to establish strategic goals and objectives
• Communicate screening plans and updates to leadership and multidisciplinary teams
• Maintain toxicology expertise through collaborations within TPPIT & PSTS globally, DPDS, and through organizational associations, literature reviews, continuing education, and publications
• Partner with Global Lead of Cellular & Molecular Toxicology, as well as Safety Pharmacology leads to establish strategic goals and objectives
• Identify topics appropriate for internal and external scientific publication, author scientific publications, posters and or draft documents for official communication (i.e. Contributing Scientist Reports, weight of evidence packages)

Education: A minimum of a Ph.D. and postdoctoral work in Toxicology, Pharmacology, Biology or…