Postdoctoral research associate
Listed on 2026-01-24
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Research/Development
Research Scientist -
Healthcare
We are seeking a highly motivated Postdoctoral Researcher towork on aresearch projectcontributingtoaninnovative therapeutic approach for muscular dystrophies.
The project aims to investigate the role of the fusogenic transmembrane proteins Mymk and Mymx in skeletal muscle homeostasis and regeneration,andhowtheirdysregulated expression contributes to impaired muscle regeneration, increased apoptosis, and tissue atrophy in dystrophic conditions,with particular emphasis on LAMA2-related muscular dystrophy (LAMA2-RD).Using both in vitro models (dystrophic satellite cells and myofibers) and in vivo approaches (mouse model of complete Laminin-211 deficiency), the candidate will study the impact of altered Mymk/Mymx expression on cell cycle regulation and apoptosis by fine-tuning their expression at different developmental time points.
and Responsibilities
- Design and perform in vitro experiments using satellite cells and myofibers
- Conduct in vivo studies in murine models of muscular dystrophy
- Manipulate gene expression (over-expression, knockdown, fine regulation strategies)
- Analyze molecular and cellular pathways related to cell cycle, apoptosis, and muscle regeneration
- Perform transcriptomic and molecular data analysis
- Contribute to manuscript preparation and dissemination of results
- Maintain accurate and complete records of all findings.
- PhD in Biology, Molecular Biology, Biomedical Sciences, or related fields
- Experience with cell culture, molecular biology techniques, and gene expression analysis
- Experience with mouse models and in vivo readouts
- Ability to work independently and as part of a team
- Creativity in problem solving, a flexible approach to tasks and adaptability
- Strong background in muscle biology and/or neuromuscular disorders
- Experience with omics data analysis
- Familiarity with apoptosis and cell cycle assays
- Experience with protocols optimization
- Prior experience with using an electronic lab notebook
Send CV to Prof. Stefano Previtali (previtali.stefano) and Dr. Veronica Pini (pini.veronica).
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