Senior Scientist

Overview

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. Summit believes in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people.

Our employees are the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s Team is Inspired To Touch And Help Change Lives Through Summit’s Clinical Studies In The Field Of Oncology. Summit has multiple global Phase 3 clinical studies, including:

• HARMONi:
  Phase 3 study evaluating ivonescimab with chemotherapy vs placebo plus chemotherapy in EGFR-mutated, locally advanced or metastatic non-squamous NSCLC previously treated with a 3rd generation EGFR TKI.
• HARMONi-3:
  Phase 3 study evaluating ivonescimab with chemotherapy vs pembrolizumab with chemotherapy in first-line metastatic NSCLC.
• HARMONi-7:
  Phase 3 study evaluating ivonescimab monotherapy vs pembrolizumab monotherapy in first-line metastatic NSCLC.
• HARMONi-GI3:
  Phase 3 study evaluating ivonescimab in combination with chemotherapy vs bevacizumab with chemotherapy in colorectal cancer (CRC).

Ivonescimab is an investigational therapy not approved by regulators other than China’s NMPA. Summit is headquartered in Miami, Florida, with additional offices in California, New Jersey, the UK, and Ireland.

The Senior Scientist will take primary ownership of laboratory activities. It is a hands-on position to drive the research of the mechanism of action (MOA) of ivonescimab and related bispecific antibodies, and to play an integral role in the discovery and development of pipeline molecules.

• MOA Research:
  Design and execute in vitro and in vivo studies, work with CROs and academic labs to elucidate the mechanism at the molecular, cellular and tumor-immune system levels. Translate the findings into a deeper understanding of therapeutic efficacy and resistance biology in different cancer indications that can guide indication expansion, rational drug combinations, and biomarker development.
• Pipeline Development:
  Design and execute experiments to create, characterize and advance the development of candidate molecules.
• Contribution to cross-functional governance:
  Produce in-depth analyses as well as executive summaries to inform internal stakeholders. Serve as the subject matter expert in cross-functional teams to facilitate decision-making. Author conference abstracts and presentations, submit manuscripts to peer-reviewed journals to share findings with the scientific and medical communities.
• Contribution to competitive intelligence collection:
  Evaluate emerging technologies, literature, and competitive landscapes to inform innovation and pipeline development.
• All other duties as assigned, including the maintenance of Summit research facilities.

• PhD with 3+ years or MS with 5+ years industry experience in Immunology, Cancer Biology, Molecular/Cellular Biology, or related fields.
• Demonstrated expertise and a strong publication record in immuno-oncology and/or angiogenesis biology fields.
• Strong technical skills in the design, execution and data analysis using wild type or genetically engineered syngeneic tumor models in mice, as well as xenograft/PDX tumor models; using organoid systems and primary human leukocytes.
• Technical proficiency in design, execution and data analysis using 10+ colors flow cytometry analyzers and sorters.
• Candidates with expertise in multiplex IHC or fluorescent microscopy, single-cell RNAseq, or spatial transcriptomic technology platforms will be highly desirable.
• Candidates with skills in antibody screening, such as affinity measurements and reporter gene assays for target binding or blockade will be highly preferable.
• Strong record of scientific communication (presentations, posters/manuscripts) and cross-functional collaboration.

The pay range for this role is $135,000-$160,000 annually. Actual compensation packages are based on several factors that are unique to each candidate, including skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package may also include bonus, stock, benefits and/or other applicable variable compensation.

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