Research Scientist in CRISPR Genomics, Engreitz Lab; LSRP

Overview

The Laboratory of Jesse Engreitz (Dept of Genetics, BASE Initiative) is seeking a Research Scientist in CRISPR Genomics (Life Science Research Professional
3) to lead large-scale data production projects to understand the genetic basis of heart diseases. The Engreitz Lab is located in the Biomedical Innovations Building on the Stanford main campus and is a member of the BASE Initiative in the Betty Irene Moore Children’s Heart Center.

Project overview: DNA regulatory elements in the human genome harbor thousands of genetic risk variants for common and rare heart diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions — if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes, and genes with thousands of pathways across diverse cell types.

We have developed approaches to enable mapping this regulatory wiring at massive scale and have applied these approaches to understand the genetic basis of complex diseases. We aim to expand these studies to systematically map the functions of variants, enhancers, and genes in many cell types from the heart and vasculature. These studies will help uncover biological mechanisms of congenital heart defects, coronary artery disease, and other heart diseases to guide diagnosis and therapeutic development.

For information, see https://(Use the "Apply for this Job" box below). and .

We are looking for a creative and passionate Research Scientist (PhD-level) to lead the next phase of our efforts to perturb the genome to understand genome function and phenotype. The ideal candidate would lead independent projects, design and supervise large-scale CRISPR data generation projects, manage collaborations with NIH-led consortia, and play a leading role in writing publications and grants. The Engreitz Lab provides a dynamic, interdisciplinary workplace with access to cutting-edge technologies and scientific thought, with potential for recognition of scientific contributions.

We value diversity of values, backgrounds, and approaches to solving problems.

The candidate should have hands-on experience in cellular genomics, molecular biology, and technology development; experience with quantitative data analysis and interdisciplinary collaboration; curiosity in research and creativity in problem solving; strong interpersonal and collaboration skills; experience building or managing teams; outstanding verbal and written communication abilities; ability to adapt to a fast-paced and dynamic environment; and a passion for science to advance medicines for patients.

In addition to submitting your application via the Stanford web portal,  and cover letter directly to Prof. Jesse Engreitz (engreitz).

This is a 2-Year Fixed-Term position, with extension possible.

Duties include:

• Make fundamental discoveries about gene regulation and the genetics of cardiovascular disease
• Together with PI and lab members, design and execute scientific projects
• Collect comprehensive perturbation datasets to inform genome function and enable training predictive models
• Develop and apply strategies to study enhancers and genes in human cells and mouse models
• Evaluate and recommend new emerging technologies, approaches, and problems
• Supervise, train, and collaborate with other lab members in experimental techniques and scientific design
• Design and lead independent projects
• Collaborate with a team of experimentalists and computational biologists
• Create scientifically rigorous visualizations, communications, and presentations of results
• Contribute to generation of protocols, publications, and intellectual property

* - Other duties may also be assigned.