Director of Protein Engineering

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Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people.

Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:

Non-small Cell Lung Cancer (NSCLC)

HARMONi:
Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

HARMONi-3:
Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

HARMONi-7:
Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

HARMONi-GI3:
Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

The Director level Protein Engineer will lead and drive innovative therapeutic protein discovery within Research focusing on the discovery, design, and optimization of novel therapeutics for cancer treatment. The ideal leader will have extensive hands-on experience in molecular biology, protein expression/purification, and the characterization of antibodies and multi specific formats and a proven track record of guiding complex biologics from early-stage design through to candidate selection.

• Drive multiple drug discovery programs concurrently, ensuring efficient progression from conceptual design to the selection of clinical development candidates, meeting aggressive project timelines.
• Lead the design, development and engineering of novel protein therapeutics, including antibodies and bispecific/multimeric molecules, to enhance function, stability, safety and develop ability for oncology applications.
• Utilize molecular engineering approaches driven by AI/ML, novel display technology, directed evolution and structure-guided design, to optimize protein candidates.
• Perform hands-on protein expression in transient eukaryotic systems (e.g., HEK
  293, CHO cells) and generate stable expression cell lines.
• Execute protein purification using various chromatography techniques (affinity, IEX, SEC, etc.) and FPLC/HPLC systems.
• Conduct comprehensive analytical and functional characterization of engineered proteins using techniques such as SDS-PAGE, ELISA, flow cytometry, SPR/BLI, and endotoxin measurement.
• Collaborate with cross-functional teams to drive projects from target validation through candidate nomination.
• Troubleshoot experiments, develop new protocols, and document findings in electronic lab notebooks and technical reports.
• Present data and research updates effectively at internal meetings and external scientific conferences.
• Stay current with the latest advancements in protein engineering, cancer biology, and immunotherapy to propose and implement innovative technologies.
• All other duties as assigned