Scientist, Functional Genomics

About Arc Institute

The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

• Funding:
  Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.
• Technology:
  Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.
• Support:
  Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
• Culture:
  We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc has scaled to nearly 200 people, with $650M+ in committed funding and a state-of-the-art new lab facility in Palo Alto, and will continue to grow quickly in the coming years.

We are seeking a highly skilled and motivated Scientist with a strong background in functional genomics and single cell sequencing to join the Functional Genomics team inside the Genome Engineering Technology Center at the Arc Institute. This position will primarily involve applying cutting‑edge functional genomics approaches for high‑throughput interrogation of mammalian genomes, transcriptomes and epigenomes with rich multi‑omic readouts.

You will play a critical role in driving the Virtual Cell Initiative, which aims to create the first foundational model that makes accurate predictions of cellular states and their response to intervention. You will have the opportunity to work closely with other Scientists and Research Associates in Arc’s Technology Centers as well as pioneering Core Investigator labs that have developed the fundamental toolbox for genome engineering and functional genomics screens, such as CRISPR nucleases, CRISPRi, CRISPRoff, CRISPRa, and serine or bridge recombinases.

The successful candidate will work with other scientists in the team to develop and optimize groundbreaking functional genomics technologies at Arc, and lead efforts to apply these technologies to generate large‑scale in‑vitro perturbation datasets across diverse cell types. Efforts will be focused on stem cells and other differentiated cell types. The candidate will also collaborate cross‑functionally with other members of Arc’s Tech Centers in a dynamic environment to drive innovative scientific discoveries and achieve Arc’s overarching goals.

• Passionate about science and excited about answering questions related to cellular identity and states, immunology, neurobiology and complex human diseases.
• Embraces challenges and often formulates creative solutions to develop new approaches and optimize existing tools to answer complex biological questions.
• Committed to generating high quality data and maintaining good documentation practices.
• Enjoys working collaboratively with others and thrives in a fast‑paced, dynamic work environment.
• Detail‑oriented, diligent, and excels at troubleshooting.
• Excellent at organization, time management and task prioritization, and enjoys driving multiple projects in parallel.

• Independently execute large in‑vitro perturbation screens in diverse cell types, generate high‑quality single‑cell perturbation…