Enterprise Architect
Job in
Palo Alto, Santa Clara County, California, 94306, USA
Listed on 2026-01-27
Listing for:
Guardant Health
Full Time
position Listed on 2026-01-27
Job specializations:
-
IT/Tech
AI Engineer, Data Science Manager, Systems Engineer, Data Engineer
Job Description & How to Apply Below
21 hours ago Be among the first 25 applicants
Company Description
Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.
For more information, visitguardanthealth.comand follow the company onLinked
In,X (Twitter) and Facebook.
Company Description
Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.
For more information, visitguardanthealth.comand follow the company onLinked
In,X (Twitter) and Facebook.
About
The Role
We are seeking a strategic and hands-on Enterprise Architect to design and evolve Guardant’s technology ecosystem as we scale 5x over the next two years. This role is enterprise-wide, with authority to establish architectural standards, guide platform development, and accelerate delivery of reusable services and components across the business.
The Enterprise Architect will partner with engineers, product, security, data science, and clinical operations teams to ensure our systems are scalable, secure, compliant, and patient-impact driven.
Key Responsibilities
• Strategic Enterprise Architecture Define and govern Guardant’s enterprise architecture, aligning technology capabilities with business priorities and oncology innovation goals.
• Reusable Platforms & Components Design shared platforms, modular services, and reusable components that enable faster delivery, reduce duplication, and improve scalability.
• Scale & Performance Architect cloud-based systems to handle 5x growth in lab throughput, data analytics, and digital engagement within 24 months.
• Data & Analytics Enablement Define enterprise data strategies and platforms for governance, interoperability, real-time analytics, and AI/ML pipelines.
• Cloud Transformation Drive an cloud-first architecture (AWS), ensuring resilience, elasticity, security, and cost efficiency at scale.
• Security & Privacy by Design Embed security and privacy controls into every platform, ensuring compliance with HIPAA, GDPR, CLIA, CAP, and FDA (21 CFR Part 11).
• Governance & Standards Establish reference architectures, patterns, and frameworks to reduce technical debt, improve adoption, and enforce consistency across engineering teams.
• Innovation & Emerging Tech Evaluate and introduce new technologies (e.g., automation, event-driven architectures, AI/ML accelerators) that strengthen Guardant’s competitive edge.
• Influence & Mentorship Act as a trusted advisor to the engineering leaders, while mentoring architects and engineers across the company.
Qualifications
• 10+ years of progressive experience in software engineering and architecture, with 5+ years in enterprise/solution architecture leadership.
• Bachelor’s degree in Computer Science, Management Information Systems, Software Engineering, Electrical Engineering, Computer Engineering, Information Systems, Bioinformatics, or a related technical field required.
• Proven ability to design and scale digital and enterprise platforms in cloud (AWS) environments.
• Strong expertise in modular architectures, reusable platforms, and component-driven design.
• Experience with lab informatics, clinical systems, or healthcare data platforms strongly preferred.
• Deep knowledge of security,…
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