Research Facility Scientist

Position Overview

Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, Genome Engineering Services Facility, John Radcliffe Hospital, Headington, Oxford, OX3 9DS
We have an exciting opportunity to join the Institute as a Research Facility Scientist within the MRC WIMM Genome Engineering, Transgenics and Virus Production Facility. The Facility is a core service with expertise in establishing genetically modified model systems. We employ a broad range of molecular biology techniques alongside CRISPR-based genome editing technologies to produce validated, ready‑to‑use reagents, including genetically modified mouse models and engineered cell lines, in support of cutting‑edge biomedical research.,

As Research Facility Scientist, you will contribute to all aspects of model generation and validation. Responsibilities will include:

• Design and construction of molecular reagents and targeting constructs
• Mammalian cell culture and genome editing
• Molecular genetic validation of edited lines
• Embryo manipulation and transgenic model production
• Cryopreservation (embryo and sperm freezing)
• Rederivation of mouse lines via IVF and embryo transfer
• Management of mouse colonies

You will work closely with researchers across the Institute to deliver high‑quality, reproducible model systems that underpin innovative scientific programmes.

You will hold a degree in Biological Sciences (or a closely related discipline) and have relevant laboratory experience. Essential experience required includes:

• Molecular biology techniques
• CRISPR genome editing
• Mammalian cell culture
• Transgenic model generation
• Mouse colony management
• Cryopreservation and rederivation techniques

You will also demonstrate excellent interpersonal and communication skills, strong organisational ability, and a clear commitment to supporting high‑quality scientific research.

This is a full‑time (37.5 hours per week) fixed‑term position for 3 years.