Principal Biostatistician; RWE Specialist - NA and Europe

Principal Biostatistician (RWE Specialist - NA and Europe)

Updated: November 5, 2025
Location: USA-NC-Remote

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities.

Our Clinical Development model brings the customer and the patient to the center of everything that we do. We are continuously looking for ways to simplify and streamline our work to not only make Syneos Health easier to work with, but to make us easier to work for.

Whether you join us in a Functional Service Provider partnership or a Full‑Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to accelerate the delivery of therapies, because we are passionate to change lives.

• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to our Total Self culture – where you can authentically be yourself. Our Total Self culture is what unites us globally, and we are dedicated to taking care of our people.
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because when we bring together diversity of thoughts, backgrounds, cultures, and perspectives – we’re able to create a place where everyone feels like they belong.

• Must be located in NA or Europe. If in NA must be open to working EST hours.
• Previous lead industry experience within RWE/RWD is required.
• Understand and be familiar with licensed RWD database.
• Independently identify, access, and assess in‑house real‑world data sources (EHRs, claims, registries, etc.) relevant to clinical trial populations and endpoints.
• Access and summarize non‑patient‑level real‑world data (publications, aggregate claims or EHR analytics, federated learnings, external collaborations, etc.) relevant to clinical trial populations and endpoints.
• Critically evaluate data quality, completeness, and suitability for specific trial design questions.
• Develop RWD exploration plans.
• Clean, process, and harmonize raw RWD for analysis, applying data governance and privacy standards.
• Use SAS, R, Python and/or other advanced analytical programming tools to perform statistical analyses and generate insights on patient characteristics, treatment patterns, outcomes, and epidemiology.
• Prepare clear, concise evidence summaries and visual reports to inform protocol development (inclusion/exclusion criteria, endpoints, comparator selection, feasibility assessments, etc.).
• Collaborate cross‑functionally with clinical, regulatory, biostatistics, and medical teams.
• Stay current on RWD methodologies, regulatory guidance, and technological advances in the field.
• Ensure all work supports timely, high‑quality decision making for new clinical trial design and execution.
• Develop new innovative RWD analytical tools where needed.

Previous lead industry experience within RWE/RWD is required.

• Company car or car allowance.
• Health benefits to include medical, dental, and vision.
• Company match 401(k).
• Eligibility to participate in Employee Stock Purchase Plan.
• Eligibility to earn commissions/bonus based on company and individual performance.
• Flexible paid time off (PTO) and sick time (subject to applicable state or municipal requirements).

The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.

Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will…