Senior Site Contracts Manager; Sponsor Dedicated​/Remote

Senior Site Contracts Manager (Sponsor Dedicated /Remote – US Based)

Updated: January 16, 2026
Location: Morrisville NC, United States
Job :-OTHLOC-1500-2

DVT-2DR

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities.

As a Senior Site Contracts Manager
, you will be responsible for developing, negotiating, and managing US site budgets and clinical trial agreements. You will collaborate closely with internal teams, external stakeholders, and major academic institutions to craft robust contracts that support operational excellence while minimizing risk.

• Build US site budget templates and study–specific budget language for Pharma & Vaccine clinical trials.
• Develop and refine templates to support consistency, compliance, and strategic study needs.

• Lead direct negotiations with large academic institutions and other critical stakeholders.
• Draft and finalize clinical trial agreements that balance business objectives with legal and operational protections.
• Conduct due diligence checks—such as FMV assessments and site justification reviews—when initial offers are declined.
• Determine when requests require budget or language escalation and secure appropriate approvals.

• Prioritize and lead multiple contracting projects across several therapeutic areas (oncology experience strongly preferred).
• Proactively elevate risks, timeline impacts, or delays that could affect CTA execution.

• Demonstrate expert proficiency in Excel and clinical trial management systems.
• Communicate effectively in both written and verbal formats, incorporating feedback seamlessly.
• Maintain accurate and timely updates in departmental trackers and databases.

• Deepen and maintain knowledge of GCP, sponsor processes, SOPs, work instructions, and new technologies.
• Build strong working relationships with internal and external partners.
• Support and train additional team members as needed.
• Contribute to process improvement initiatives that simplify workflows and eliminate inefficiencies.
• Take on ad‑hoc tasks and diverse projects with a solutions‑oriented mindset.

• Oncology therapeutic area experience
• Prior experience with pharma, CRO, or investigative sites
• Strong project management skills and comfort leading cross‑functional efforts

• 4+ years building budgets and contracts from templates
• Direct experience negotiating with large academic institutions
• Ability to juggle priorities, lead projects, and deliver results under tight timelines
• Strong understanding of clinical study protocols, timelines, and site–related milestones (e.g., SIV)
• Bachelor’s degree

At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time.

Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.

Salary Range: $79,800.00 - $

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.

Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with…