Director, Launch Excellence

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical‑stage company currently focused on post‑bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

Amylyx is seeking a Director, Launch Excellence to play a critical role in planning and executing the successful commercial launch of our first product in the endocrinology space. This role will be hired in 2026 and will partner cross‑functionally to ensure launch readiness ahead of a potential 2027 product launch.

The Director, Launch Excellence will serve as the central coordinator for launch activities—driving disciplined execution, clarity of ownership, and visibility across Commercial, Medical, Clinical, Regulatory, Manufacturing, Market Access, Finance, Legal, and IT. This is a hands‑on role requiring strong project leadership, judgment, and the ability to operate effectively in a fast‑growing biotech environment.

• Lead the end‑to‑end launch execution plan, including timelines, milestones, dependencies, and risk mitigation activities.
• Translate high‑level launch strategy into actionable, trackable work streams with clear ownership.
• Maintain and continuously refine integrated launch plans from pre‑approval through post‑launch phases.

• Act as the single point of coordination across all launch‑related functions.
• Facilitate regular launch governance forums (e.g., launch team meetings, executive readouts).
• Ensure continuous alignment across Commercial, Medical Affairs, Market Access, Supply Chain, Regulatory, and other key stakeholders.

• Proactively identify launch risks, gaps, and interdependencies; develop mitigation plans and elevate as needed.
• Track launch readiness metrics and ensure timely decision‑making.
• Support scenario planning tied to regulatory timing, supply readiness, and market dynamics.

• Implement and manage launch project management tools, dashboards, and reporting mechanisms.
• Drive consistent ways of working, documentation standards, and decision logs.
• Prepare detailed and clear executive‑level communications and launch status updates.
• Capture lessons learned and best practices to support future indications or lifecycle expansion.
• Help build scalable launch excellence capabilities appropriate for a growing biotech organization.

• Bachelor’s degree required; advanced degree (MBA, MPH, MS) preferred.
• 10+ years of experience in pharmaceutical or biotech launch, commercial operations, or enterprise project management.
• Direct experience supporting product launch readiness in the U.S. market.
• Proven ability to lead complex, cross‑functional initiatives without direct authority.
• Strong organizational, communication, and stakeholder management skills.
• Fluency with project management tracking tools (e.g., MS Project, Smartsheets, MS Excel), and advanced MS PowerPoint skills.
• Comfortable operating in ambiguity and adapting as strategy and timelines evolve.

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis.
• When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy,…