Group Leader - Senior Director, Quantitative Pharmacology and Pharmacometrics; Hybrid or Remote

Overview

This role provides strategic leadership and scientific oversight to part of the cardiometabolic (CMD) therapeutic area (TA) portfolio in the department of Quantitative Pharmacology and Pharmacometrics (QP2). The Team Leader (Senior Director) is responsible for applying cutting-edge quantitative pharmacology and pharmacometrics strategies to propel the internal portfolio forward, leveraging the full strength of the QP2 department. The CMD TA Team Leader will oversee a team of QP2 scientists, providing guidance in personnel management, scientific strategy, and operational execution, and serve as QP2 lead on assigned projects.

The role reports directly to the QP2 CMD Head and collaborates with the QP2 CMD leadership team and broader organization to ensure consistent, high-value quantitative pharmacology contributions throughout the CMD portfolio from discovery through life cycle management. The role is part of the extended QP2 leadership team and contributes to one or more business or talent facing work streams. Senior Directors are recognized as scientific thought leaders who develop and implement translational PK/PD strategies, characterize clinical pharmacokinetics and pharmacodynamics, and influence regulatory strategy, dose selection, and go/no-go decisions.

• Lead a team of up to 4 QP2 scientists, including people management, scientific and operational oversight, under the direction of the Executive Director of QP2-CMD.
• Provide day-to-day scientific oversight to individual contributors by leveraging end-to-end drug discovery/development and disease area expertise.
• Set priorities for direct reports and drive performance management, hiring and retention, staff development and training, and input into calibration and talent management processes.
• Serve as an expert representative for QP2 on discovery and drug development teams and engage in cross-functional and governance discussions, including business development and licensing evaluations.
• Maintain a comprehensive understanding of global regulatory expectations for small molecules and biologics, contribute to cross-functional regulatory strategy, and author regulatory documents (INDs, CSRs, CTDs).
• Develop and apply mechanistic, disease progression and comparator modeling platforms to inform portfolio decisions.
• Partner with the Executive Director of CMD to identify resource needs and contribute to internal resource allocation.
• Serve as QP2 lead on assigned projects.

• Ph.D./Pharm
  
  D or equivalent with at least 10 years of experience in pharmaceutical drug development or regulatory, with a record of increasing responsibility and independence in a similar role.
• Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, engineering, mathematics/biostatistics, computational biology/chemistry, or related field.
• Extensive experience in developing quantitative strategies to impact pipeline decisions and drug development expertise.
• Demonstrated ability to lead an interdisciplinary team or oversee the work of others.
• Experience working in an inclusive, high-performance environment and applying enterprise ways of working principles, including collaboration and result delivery while managing ambiguity.
• Relevant regulatory and quantitative pharmacology experience.
• Proficiency in written and verbal communication and interdisciplinary collaboration, with strong problem solving and planning skills.

• CMD therapeutic area or disease knowledge.
• Expert skills in population PK/PKPD analyses using standard pharmacometrics software (e.g. NONMEM, R, Monolix, Phoenix, etc.).
• Scientific understanding of biopharmaceutical and ADME properties across modalities.
• Track record of applying models to inform decisions.
• Ability to influence regulatory strategies, including prior experience independently authoring and defending regulatory filings (NDA/MAA).
• Recognized leader in quantitative pharmacology with external visibility through publications, presentations, or professional involvement.

The remote position is available only for those not within commutable distance to primary sites. If commutable, the position will be hybrid. The posting includes notes on hybrid work and location-related details.

Requirements and Additional Details include: salary range, benefits, relocation, visa sponsorship, travel, and hybrid work model. The salary range is $ - $ and bonuses/long-term incentives may apply. Benefits include medical, dental, vision, retirement, holidays, vacation, and sick days. Information on benefits is available at the company compensation page. Applications can be submitted via the company careers site or Workday for current employees.

The posting end date is 02/07/2026.

U.S. Equal Employment Opportunity Employer. The company provides equal opportunities to all employees and applicants and prohibits discrimination. The firm complies with affirmative action requirements for protected veterans and individuals with…