Senior Clinical Trial Associate

About Entrada Therapeutics

Entrada is a clinical‑stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Our Endosomal Escape Vehicle (EEV™)-therapeutics enable efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, improving therapeutic index. Through this proprietary, versatile and modular approach, we are advancing a robust development portfolio of RNA‑ and protein‑based programs for potential treatment of neuromuscular and ocular diseases, among others.

Our lead oligonucleotide programs target Duchenne muscular dystrophy exon 44, 45, 50 and 51 skipping, and we have partnered to develop a clinical‑stage program, VX‑670, for myotonic dystrophy type 1.

We are looking for a patient‑focused individual excited about supporting and developing the Clinical Operations organization  thrive in a fast‑paced environment, juggle competing priorities, follow up and follow through, and connect problems with efficient solutions. You work successfully in a team, building strong interpersonal relationships inside and outside the company.

This position will assist the clinical operations team in day‑to‑day operations, study start‑up and set‑up, execution, and closeout of assigned trials. The individual is accountable to the clinical trial team for trial execution support and works collaboratively with cross‑functional team members and vendors to ensure proper set‑up of trial processes and plans, executing the protocol in accordance with established SOPs and standards.

• Support day‑to‑day operations of assigned trials to ensure completion per established project team goals and objectives, in compliance with ICH/GCP guidelines, from study start‑up to close‑out.
• Provide accurate and up‑to‑date clinical trial information within relevant tracking tools and give regular updates of trial progression to the clinical trial team, including protocol deviations, adverse events, and site personnel training.
• Contribute to the development of trial‑related plans and manuals.
• Ensure timely maintenance of the Trial Master File (TMF), filing and reconciliation according to regulatory guidance and internal SOPs.
• Participate and ensure appropriate documentation of clinical team meetings, including meeting minutes, agendas, and action items.
• Manage vendor purchase orders and trial payments (including budget reconciliation), including invoice review and approval.
• Assist in external training activities (suppliers, clinical sites, etc.).
• Assist in managing trial completion activities, including data review, database lock, and trial closeout.

• Humanity – We genuinely care about patients and about one another.
• Tenacity – We are relentless and persistent in pursuing therapies for patients.
• Creativity – We are creative problem solvers.
• Collaboration – We are more than the sum of our parts.
• Curiosity – We have a growth mindset and push conventional thought and theory.

• BA/BS degree with at least 2 + years of relevant experience in clinical operations working directly at a biotech or pharmaceutical company.
• Strong understanding of clinical trial operations across varying phases, from study start‑up to close‑out.
• Direct experience managing and providing oversight of the TMF.
• Ability to work independently and take initiative on projects under minimal supervision.
• Working knowledge of drug development and ICH/GCP guidelines.
• Previous CRO or vendor management experience preferred.
• Excellent interpersonal, written, administrative, and computer skills.
• Excellent verbal and written communication skills with a strong attention to detail.
• This role is a long‑term contract position that follows a remote working model, requiring monthly or quarterly travel to the Entrada Therapeutics Headquarters in Boston, MA. Preference will be given to New England‑based candidates.

Entrada Therapeutics is an equal‑opportunity employer. Qualified candidates will receive consideration for employment…