Research Specialist | School of Medicine – Pediatrics

Overview

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Research in the Obeng lab centers on the pathogenesis of myeloid malignancies including clonal hematopoiesis (CH), myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). We are investigating how acquired somatic mutations in hematopoietic stem cells lead to clonal expansion and malignant transformation. Mutations in components of the mRNA splicing machinery and epigenetic regulators are common and early events in MDS. The major interests of the Obeng lab are (1) determining how mutations in components of the mRNA spliceosome and epigenetic regulators cooperate to cause clonal hematopoiesis and leukemia (2) identifying and studying novel treatments that selectively target mutant stem cells and (3) determining the incidence and clinical significance of clonal hematopoiesis of indeterminate potential (CHIP) in pediatric cancer survivors.

• Under general supervision, performs a variety of defined research and laboratory tests and experiments according to prescribed protocols and assigned schedules.
• Sets up experiments as prescribed by a principal investigator.
• May be required to participate in laboratory maintenance activities such as sterilization and cleaning of equipment, ordering of supplies, inventory and media preparation.
• Maintains records, files and logs of work performed in laboratory notebooks and computer databases.
• Compiles data and records results of studies for publications, grants and seminar presentations.
• Employees in this classification may be required to work with, take specific precautions against and/or be immunized against potentially hazardous agents.
• Performs related responsibilities as required by principal investigator.

• We are seeking a highly motivated individual with an interest in biomedical research.
• The ideal applicant will utilize state-of-the-art techniques in genetics, molecular biology, and cell biology to characterize in vitro and in vivo models of human diseases with a particular focus upon RNA splicing factor mutations and their relationship to MDS and leukemia.
• You will have the opportunity to develop and lead projects using several cutting-edge model systems including isogenic immortalized cell lines generated using CRISPR-Cas9 gene editing, novel xenograft and transgenic in vivo systems, and primary patient samples.
• In this position, you will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study development.
• Successful applicants will have an interest in basic and translational research and respond well to a busy and dynamic lab environment.

• Bachelors degree in a scientific field OR equivalent combination of experience, education, and training.

Note:

Position tasks are generally required to be performed in-person at an Emory University location. Remote work from home day options may be granted at department discretion. Emory reserves the right to change remote work status with notice to employee.

Emory is an equal opportunity employer, and qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by state or federal law. Emory University does not discriminate in admissions, educational programs, or employment, including recruitment, hiring, promotions, transfers, discipline, terminations, wage and salary administration, benefits, and training.

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