Senior Medical Director, Clinical Development - Neuroscience

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.

In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling: ARV-102 for the treatment of patients with neurodegenerative disorders, ARV-393 for the treatment of patients with relapsed/refractory non‑Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for the treatment patients with solid tumors with KRAS G12D mutations.

On August 8th 2025, the U.S. Food and Drug Administration (FDA) accepted the New Drug Application (NDA) for vepdegestrant‑ an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1‑mutated advanced or metastatic breast cancer previously treated with endocrine‑based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out‑licensing and commercialization of vepdegestrant.

In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTACandrogen receptor protein degrader ARV‑766 for the treatment of prostate cancer. The transaction closed in May 2024.

#Team Arvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform.

We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.

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Arvinas is looking for an experienced Senior Medical Director with the passion and creativity to develop great medicines for neuromuscular and neurodegenerative diseases. The ideal candidate is a physician with experience of a global drug development program and global filing experience who is enthusiastic about applying their knowledge to the cause of patients around the globe who have no approved therapies for their disease.

The individual will be a self‑starter with excellent management and leadership capabilities who is seeking to lead and be part of an innovative team that will drive the drug development processes from start to finish.

Reporting into the Vice President of Clinical Research, the Senior Medical Director will be primarily responsible for the strategy, development and execution of clinical research and development programs, including the leadership of the pivotal trials and filing activities. This position will serve as a key liaison between company and clinical investigators and establish credible relationships with opinion leaders, regulatory officials and other key stakeholders and partners.

The successful candidate will be ready for a career defining experience and have the passion to drive a number of therapeutics for serious debilitating diseases to final approval.

This role can be located at our headquarters in New Haven, CT or work with a hybrid or remote work arrangement from a location within the U.S.

Key responsibilities of this role include, but are limited to:

• Partner…