Director, Clinical Pharmacology Remote

At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from ‘day one’ to the future they’ve envisioned.

Day One Biopharmaceuticals is seeking a Director of Clinical Pharmacology to lead and drive early-stage clinical programs. This is a high-impact, hands‑on role that requires deep scientific expertise, a rigorous understanding of antibody drug conjugates (ADC), and a proactive, solution‑oriented mindset. The position reports to Vice President, Clinical Pharmacology.

The successful candidate will serve as the Clinical Pharmacology Lead and subject matter expert (SME) for one or more ADC programs, playing a critical role in dose selection, optimization, and the integration of pharmacologic and clinical insights. The ideal candidate thrives in detail – taking full ownership of data analysis and interpretation – and is motivated to make a meaningful impact on program direction and success.

This is not a purely strategic leadership role; it requires active, hands‑on involvement in all aspects of clinical pharmacology planning and execution. Success depends on deep familiarity with program data, scientific rigor, and a clear understanding of clinical development priorities.

In addition to technical excellence, the ideal candidate brings a collaborative mindset, accountability, dependability, and a strong commitment to high‑quality work. The Clinical Pharmacology team and our cross‑functional partners foster a culture rooted in trust, open communication, and mutual respect, where team members feel safe speaking up, sharing ideas, and working through challenges together.

This position has the potential to be fully remote with a preference for Boston or the San Francisco Bay Area. Occasional travel will be required for in‑person meetings.

• Serve as the Clinical Pharmacology lead for one or more ADC programs within a cross‑functional team:
  • Lead dose selection and optimization in support of early‑stage clinical development and decision‑making; serve as SME on dose selection and optimization.
  • Provide clear and actionable recommendations to the cross‑functional team through review, analysis, and interpretation of PK, PD, and exposure‑response data; serve as the primary expert on your data and discuss it confidently and accurately at any time.
  • Drive clinical pharmacology strategy and execution with direct accountability for data integrity and scientific interpretation.
  • Translate cross‑functional questions into clear, actionable clinical pharmacology objectives with defined scopes of work and timelines.
  • Author and maintain a comprehensive Clinical Pharmacology Plan, ensuring timely execution of deliverables.
  • Author or co‑author, and critically review key program documents including Investigator’s brochure, clinical trial protocols, study reports, and regulatory submission documents.
  • Collaborate with Medical Affairs to support scientific communications, including abstracts, posters, and manuscripts for conferences and peer‑reviewed publications.
  • Respond to clinical pharmacology‑related inquiries from medical monitors, investigators, and cross‑functional stakeholders.
  • Lead clinical pharmacology input and strategy for regulatory interactions, including written responses and meetings with health authorities.
  • Oversee external vendors: monitor vendor performance to ensure alignment with scientific and operational expectations and provide timely, constructive feedback to support high‑quality deliverables and effective collaboration.
• May serve as a strategic leader for the clinical program:
  • Identify and proactively resolve issues that may impact program execution (e.g., data quality or timelines).
  • Influence program direction using integrated scientific, clinical, and business insights.
  • Provide leadership…