Senior Principal Scientist, Process Chemistry

Role Summary

The Chemical Process and Analytical Development (CPAD) group in Bothell, WA develops innovative and phase‑appropriate synthetic routes and scalable chemical processes for novel small molecule components used in targeted therapeutics. Our process chemists, analytical scientists, and chemical engineers collaborate to design robust, safe, and scalable chemistry that accelerates delivery of life‑changing therapeutics to patients.

As a Senior Principal Scientist in Process Chemistry, you will serve as a key technical leader driving route scouting, synthetic design, process development, and process characterization for our expanding portfolio. You will apply a strong foundation in modern synthetic organic chemistry and process research to design and develop scalable, innovative synthetic processes to novel medicines using state‑of‑the‑art technologies such as high‑throughput experimentation, data‑rich experimentation, continuous processing, catalysis, and predictive software.

This role provides the opportunity to contribute through hands‑on laboratory innovation while guiding technical strategy for early and late‑stage programs. You will mentor junior scientists, lead cross‑functional project direction, and represent process chemistry both internally and externally. You will also oversee execution of GMP production batches through technology transfer and campaign oversight.

• Lead technical teams to design, execute, and interpret complex laboratory experiments aimed at route development, process optimization, and scale‑up.
• Lead authorship of patents, publications, and regulatory documents.
• Apply modern synthetic organic chemistry principles, high‑throughput experimentation, mechanistic insight, and data‑rich methods to accelerate development.
• Effectively communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions.
• Drive alignment to project timelines and portfolio strategy.
• Mentor junior staff and foster an inclusive, scientifically rigorous, and collaborative environment.
• Lead technology transfer and partner interactions to enable external development campaigns.
• Build strong stakeholder relationships across process chemistry, partner functions, and project teams.
• Maintain an external technical presence through publications and presentations.

• PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development, including route design, scale‑up, and GMP manufacturing; or a Master’s degree with 15+ years of relevant experience.
• Deep foundational understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification and analytical technologies.
• Demonstrated scientific impact via peer‑reviewed publications, patents, or conference presentations.
• Strong communication skills with demonstrated collaborative leadership in cross‑functional process development teams.
• Experience supporting development from preclinical through commercial stages.
• Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.
• This is an on‑site role (5 days/week).
• Submission of a research summary is required.

• Experience developing drug‑linkers for ADCs, PROTACs, DACs or other targeted mixed‑modality therapeutics.
• Experience mentoring and developing scientific staff.
• Experience with technology transfer and oversight of external development work.
• Experience at innovator pharmaceutical companies strongly preferred.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including the ability to influence and collaborate with peers, develop and coach others, and oversee and guide the work of colleagues to achieve meaningful outcomes and create business impact.

Relocation support and assistance may be available based on business needs and/or eligibility. Work Location Assignment:
On Premise.

The annual base salary ranges from $ to $. Eligibility for Pfizer’s Global Performance Plan with a bonus target of 17.5% of base salary and participation in a long‑term…