Senior Research Scientist, ADME Bioanalytical

Senior Research Scientist, ADME Bioanalytical

Bothell, Washington, United States

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting‑edge therapies, including antibody‑drug conjugate therapies. Our pipeline includes varegacestat, a late‑clinical stage GSI; IM‑1021, a clinical‑stage ROR1 ADC; and IM‑3050, a FAP‑targeted radiotherapy that recently received IND clearance.

We are also advancing a broad portfolio of early‑stage ADCs pursuing undisclosed solid tumor targets.

The Senior Research Scientist will play a key role within Immunome’s ADME and bioanalytical function, supporting the advancement of Immunome’s preclinical programs—including ADCs and other targeted oncology modalities. This position will be responsible for developing and executing bioanalytical assays, performing quantitative LC‑MS/MS analyses, preparing and extracting samples from diverse biological matrices, and supporting method development for both small and large molecules in preclinical studies.

The scientist will independently evaluate data, troubleshoot instrumentation, contribute to bioanalytical strategy, and communicate findings to cross‑functional teams. This role will also support externalized studies by preparing method transfer documentation and reviewing CRO data packages in support of regulated preclinical studies.

• Perform sample extraction and preparation from a range of biological matrices for both large and small molecule analytes.
• Develop and optimize bioanalytical methods for ADCs and other modalities within preclinical settings.
• Maintain, operate, and troubleshoot chromatography and mass spectrometry instrumentation.
• Maintain a detailed and accurate electronic laboratory notebook in accordance with ALCOA+ principles.
• Evaluate bioanalytical data to support ADME studies and early research activities.
• Support pharmacokinetic, pharmacodynamic, and stability evaluations.
• Interpret and communicate bioanalytical results to the ADME group and cross‑functional project teams.
• Prioritize responsibilities effectively in a dynamic environment with evolving timelines.
• Collaborate with cross‑functional teams to align bioanalytical strategies with early research and translational objectives.
• Assist in managing outsourced bioanalytical studies, including preparation of method transfer packages and review of method validation and sample analysis reports for regulated preclinical studies.

• Bachelor’s with a minimum of 5 years or Master’s degree with a minimum of 3 years of experience in bioanalytical and/or analytical chemistry.
• Knowledge of regulatory guidance and industry best practice for LC‑MS analysis of large and small molecules.
• Demonstrated expertise in LC‑MS/MS for quantitative analysis from complex biological matrices using protein precipitation, solid‑phase extraction, immunoprecipitation, or related techniques.
• Experience with quality and statistical evaluation of data using Sciex OS, Protein Metrics, Excel, Graph Pad Prism, Chem Draw, and/or Skyline.
• Experience managing outsourced bioanalytical studies, including preparation of method transfer packages and review of method validation and sample analysis reports for regulated preclinical studies.

• Strong technical expertise in LC‑MS/MS operation, troubleshooting, and method development.
• Solid understanding of ADME principles, pharmacokinetics, pharmacodynamics, and bioanalytical workflows.
• Ability to independently analyze, interpret, and present scientific data.
• Strong organizational skills with the ability to manage competing priorities.
• Effective written and verbal communication skills supporting cross‑functional collaboration.
• Commitment to data integrity and high‑quality documentation.

Washington State Pay Range

$106,694 - $133,289 USD

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

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