Director of Development

About Amyloidosis Research Consortium

The Amyloidosis Research Consortium (ARC) is a 501(c)(3) nonprofit organization founded in 2015, harnessing the power of collaboration and innovation to advance science and improve and extend the lives of those with amyloidosis. We are dedicated to transforming the way research is being done and focus on what will have the most significant impact on improving the lives of amyloidosis patients.

We forge collaborations across industry, research, clinical care, and regulatory to address unmet needs and accelerate the discovery of new treatments. ARC empowers and supports patients by ensuring they have access to the best quality care and information. ARC now has a staff of 14 professionals, and a $4.5M budget with a Development Team revenue goal for 2026 of $1M.

Amyloidosis is a group of diseases where abnormal proteins build up in organs, causing progressive damage. In the U.S., approximately 3,800 new AL amyloidosis cases are diagnosed annually. However, ATTR amyloidosis affects far more people: over 100,000 Americans have the age‑related form, and 50,000 people worldwide have the inherited form. Studies show that roughly 13% of older heart failure patients actually have undiagnosed ATTR amyloidosis, meaning the true patient population is even larger.

As awareness and diagnosis improve, the community continues to grow.

To learn more about ARC, visit http://(Use the "Apply for this Job" box below)..

Director of Development will lead the strategic growth of ARC’s philanthropic revenue. This individual is responsible for the full donor lifecycle—from discovery to stewardship—with a heavy emphasis on high‑touch major gift fundraising. The Director will manage an active portfolio of donors and prospects, secure new institutional and foundational giving, craft donor‑facing communications and materials, empower a Board Development Working Group to expand ARC’s influence and financial sustainability, and serve as a key advisor to the CEO.

Reports to: Chief Executive Officer (CEO).

Management: Supervises Development Operations Manager, whose responsibilities include CRM/Salesforce and data management, acknowledgements and receipts, mid‑year and annual direct mail and electronic appeals, foundation and grant tracking, and donor prospecting, research and reporting to advance new constituents with major donor potential coming into the organization.

Location: Remote, organization is based in Newton, MA but team is fully remote.

Travel: 25%‑35% to meet with donors, attend staff gatherings, and related conferences and events.

Major Gift Leadership & Portfolio Management

Direct Solicitation: Own and advance a personal portfolio of 75+ major donor prospects, driving the strategy for discovery, cultivation, and engagement; actively engage in weekly 1:1 calls and emails with donors within the portfolio and to prospective donors.

Pipeline Management: Lead bi‑weekly donor pipeline review meetings with the CEO and Development Manager to ensure rigorous movement and accountability across all prospects; design, own, and maintain the structure of the donor pipeline, including stages, qualification criteria, and movement standards.

CEO Partnership: Serve as the lead strategist for the CEO’s portfolio of 25+ top‑tier prospects, providing research, briefing materials, and follow‑up support necessary to close transformational gifts.

Communications & Operations Oversight

Messaging & Collateral: Craft compelling donor‑facing materials, including the Case for Support, impact narratives, and mission‑driven storytelling.

Program Alignment: Ensure alignment between fundraising strategy, communications, and program needs; organize and manage work with program/department leads to produce major donor materials.

Revenue Ownership: Own all development revenue targets and forecasting, using a clear, disciplined methodology to set achievable growth goals, regularly reforecasting to flag risks early.

Team Management:

• Data Integrity: Oversight of Salesforce/CRM management and reporting.
• Annual Giving: Execution of mid‑year and annual direct mail/electronic appeals.
• Donor Intelligence: Robust research and…