Glyco-Engineering Scientist

This position is based out of New York, NY. Relocation assistance is available.

Neion Bio is harnessing nature’s best protein factory to bring about a world of healthy abundance. Through genetic engineering, we’re creating “living bioreactors”, which act as fully autonomous 3D biomolecular printers, using existing industrial-scale infrastructure. Our platform can rapidly and scalably produce almost any protein, provide national resilience to drug shortages and de-risk complex supply chains, and ultimately take advantage of novel biological environments to solve unmet medical needs.

We are looking for a talented scientist with expertise in glyco-engineering, glycobiology, protein analytics and protein purification to support our ambitious synthetic biology projects. We will be glyco-engineering mammalian and avian cells, and create glyco-engineered transgenic animals. You will work with a talented group of engineers and biologists committed to developing disruptive, novel protein production technologies.

• Develop rapid glyco-analysis assays
• Develop and execute a glyco-engineering strategy that enables specific desired glycoprofiles in cell lines and transgenic animals
• Characterize purified proteins using a range of analytical techniques (e.g., SDS-PAGE, HPLC, mass spectrometry)
• Develop and execute binding and potency assays for monoclonal antibodies

• Present findings at R&D meetings
• Maintain a thorough and detailed electronic lab notebook
• Maintain a clean and organized laboratory environment

• PhD/MS in synthetic biology, bioengineering, glycobiology, molecular biology, biochemistry or related field
• 3+ years hands‑on expertise in glyco‑engineering and glyco‑analysis
• Understanding and hands‑on experience with current precision editing techniques, covering the design, optimization and verification of genome edits
• Experience with avian or mammalian cell culture, DNA/RNA transfection, bacterial culture, recombinant DNA cloning techniques, primer design and PCR, qPCR, gel electrophoresis, nucleic acid extraction and purification
• Proficiency in modern protein purification techniques, including chromatography (affinity, ion exchange, size exclusion), ultrafiltration, and protein analytics.
• Hands‑on experience with protein characterization tools (e.g., SDS‑PAGE, Western blot, spectrophotometry, HPLC)
• Experience interpreting results from assays such LC‑MS, CD, FTIR, UV, SPR, and other therapeutic analytical characterization assays.
• Self‑motivated, proactive, works well under pressure and deadlines, detail‑oriented
• Enthusiasm for learning new skills and taking on new responsibilities
• Strong written and oral communication skills, as well as creative problem‑solving skills
• Strong emotional intelligence and passion for building relationships across all levels of an organization.
• Enjoys the fast‑paced startup environment and teamwork

• Experience with flow cytometry, immunostaining, and fluorescent microscopy
• Familiarity with multiple recombinant protein expression systems (e.g., mammalian, microbial, avian)
• Knowledge of regulatory considerations for therapeutic protein production.

We are on a mission to reimagine the way in which complex biological molecules are produced to transform human health and upend multiple billion dollar markets. At Neion Bio you will play a pivotal role in an early‑stage, fast‑growing company, working alongside leading scientists and entrepreneurs. You will have the opportunity to participate in the enormous potential upside while having a huge impact on the world.

We’re building a future of healthy abundance, one living bioreactor at a time. To do so, we’re bringing together some of the best talent in the world – including you. We’re very serious about what we do, but also serious about work‑life balance, being decent people, and loving being at work.

Compensation: base salary is expected to be $110‑150k depending on experience, with additional bonus compensation, equity compensation, and benefits.