Research Assistant | Laboratory of RNA Structural Biology and Biophysics

Organization Overviewede The Laboratory of Structural Biology and Biophysics, led by Steve Bonilla, is dedicated to unraveling the fundamental physical principles that govern the three‑dimensional shape and dynamic behavior of RNA molecules. Specifically, our focus lies in understanding the RNA sequences encoded by viruses, which enable them to manipulate the biochemical machinery of their host. To achieve this goal, we employ a wide range of cutting‑edge tools and techniques, including cryogenic electron microscopy (cryo‑EM), single‑molecule FRET, small‑angle X‑ray scattering (SAXS), as well as other biophysical and structural biology methods, alongside functional assays.

Overview

We are looking for a Research Assistant to join our team and assist with molecular biology, biochemistry, and structural biology experiments.

• Producing and purifying vitro transcribed RNA for biochemical and structural analysis
• Characterizing RNA structure by electrophoresis and biochemical methods
• Ordering reagents and preparing buffers for lab use
• Preparing samples for cryo-EM studies (e.g., freezing grids)
• Collecting and analyzing cryo-EM data (i.e., computational work)
• Presenting at group meetings and journal clubs

REQUIRED QUALIFICATIONS:

• Bachelors degree in biochemistry, chemistry, chemical engineering, or similar field
• Substantial experience with molecular biology techniques (e.g., PCR, electrophoresis, DNA purification, protein expression and purification)
• Experience following protocols
• Ability to maintain an accurate and well‑organized lab notebook

PREFERRED QUALIFICATIONS:

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  Experience in:
  • Structural biology
  • Cryo‑EM
  • RNA biology
• Computational/programming skills

The Rockefeller University is an equal opportunity employer – veterans/individuals with disabilities. Qualified applicants will receive consideration for employment without regard