Senior Research Associate, In Vivo Biology

Actinium Pharmaceuticals develops targeted radiotherapies to improve patient outcomes. Our lead candidate, ATNM-400, is a first‑in‑class Actinium‑225 (Ac‑225) therapy for prostate cancer and lung cancer, showing superior preclinical efficacy and synergy with existing treatments. Actimab‑A, targeting CD33 for AML and other myeloid malignancies, has demonstrated high remission rates in patients and is advancing to pivotal clinical trials, including combination studies with Venetoclax, ASTX‑727, and now PD‑1 inhibitors (KEYTRUDA, OPDIVO) for solid tumors.

Additional clinical programs include Iomab‑ACT and Iomab‑B for transplant conditioning. Actinium also pursues preclinical solid tumor programs and holds ~240 patents, including for Ac‑225 production. Building on our expertise and leadership in radiopharmaceuticals, Actinium is rapidly accelerating our investigational research efforts and is looking for talented scientists to join the team.

Actinium is seeking a highly motivated and skilled Senior Research Associate with prior industry experience (2 years) in biologics to actively support the Company’s promising R&D strategy to discover and develop novel cancer radiopharmaceuticals. The qualified individual will have prior experience in an industry (preferred) or academic lab setting, including experience in drug discovery and analysis, designing, and performing preclinical in vivo research studies.

This person will independently perform high quality work and collaborate with research associates and laboratory technicians. This position will directly contribute to the R&D team under the guidance of the Manager, In Vivo Biology. The candidate in this role is expected to support preclinical drug discovery and pharmacology studies in rodents and be proficient in oncology animal models, cell culture, and assay development.

Experience with non-radioactive drug formulation and handling radioactivity is preferred.

• Perform independently planned IACUC approved small animal experiments including in vivo mouse cancer models.
• Administer radioactive and non-radioactive drugs by multiple routes including IV, IP, SC, etc. Experience with non-radioactive drug formulation is preferred.
• Perform independently tumor burden measurements (e.g., using caliper and bioluminescence imaging), body weight measurements, tissue and blood collection and processing samples for ex vivo assays and biodistribution studies.
• Perform planned experiments independently with demonstrated competence in standard mammalian cell culture and aseptic technique.
• Vivarium monitoring and occasional husbandry duties (e.g., cage changing).
• Assist the Manager, In Vivo Biology with experimental planning and execution.
• Gather, interpret and analyze data from performed research experiments.
• Assist with maintaining laboratory equipment (coordinating preventative maintenance and repairs as needed), ordering of reagents and laboratory supplies.
• Maintain laboratory reagent database, including cell lines and antibodies.
• Ensure that safe laboratory practices and IACUC protocols are adhered to including the use and disposal of chemicals and hazardous materials.
• Maintain a detailed electronic laboratory notebook: prepare and maintain detailed records, logs and summary reports of all procedures and results including graphs, data analysis, scientific calculations, and statistical analysis. Experience with MS Office and Graph Pad Prism is desirable.
• Collaborate cross‑functionally with colleagues in Radiochemistry and In Vitro Biology to drive translational research.
• Contribute to a culture of scientific excellence by keeping informed on scientific advances and emerging technologies in targeted therapies for oncology.
• Contribute to company culture and team building.

• Master’s or bachelor’s degree in biological sciences with a minimum of 2 years biotech or pharmaceutical company experience in oncology product development. Minimum 3‑5 years of cancer biology lab research experience in academic setting. Industry experience is preferred.
• Demonstrated experience with handling small animals and in vivo procedures.
• Demonstrated…