Director of Clinical Data Management

At Pathos, we’re reimagining what’s possible in oncology drug development.

Founded by the team that built and scaled Tempus Labs, home to the world’s largest library of clinical and molecular data, Pathos is on a mission to revolutionize precision medicine in cancer. We’re using AI and machine learning not as buzzwords, but as fundamental tools to understand biology, identify precise disease drivers, and match patients to the therapies they truly need.

Our vision is bold: to create a new model for drug discovery and development, one rooted in deep data, integrated science, and rapid translation. We’re not building another pharma company, we’re building a platform to find better medicines, faster, and to get them to the right patients at the right time.

We’ve already begun assembling a portfolio of clinical-stage oncology assets, and we’re applying our technology to select the right indications, optimize clinical design, and increase the probability of success, from bench to bedside.

We believe that the current system moves too slowly, and too many patients are still waiting. That’s why we’re here. That’s why Pathos exists.

If you’re driven by purpose, excited by complexity, and eager to work alongside brilliant, kind, and mission-aligned teammates, we’d love to meet you.

We’re headquartered in New York City, with a distributed team across the U.S., and operate with the focus and agility of a startup while building with the scale and ambition of something much bigger.

Come help us build it.

The Director of Clinical Data Management (CDM) will establish and lead the data management function s role reports to the Vice President, Head of Clinical Operations and is ideal for a hands‑on data leader who thrives in high‑growth, fast‑moving environments and is excited to build CDM strategy, systems, and processes from the ground up.

You will own oversight of clinical data collection, cleaning, and integrity across our oncology trials, ensuring datasets are of the highest quality for analysis, regulatory submissions, and decision‑making.

Key Responsibilities

Clinical Data Strategy & Oversight

• Leads oversight of data management for outsourced clinical trials including project management, vendor management, coordination of internal reviews and data cleaning process, and approval of deliverables.
• Oversees CRO/Vendor activities to ensure GCP compliance, ensure all work is carried out in strict accordance with the relevant protocols, Standard Operating Procedures, and in compliance with Good Clinical Practices.
• Oversees data management activities to maintain consistency across trials/development projects: including Case Report Form (CRF) design and standards, Data Management Plans, CRF annotation and completion guidelines, edit check programs/specifications, data entry and query status tracking, and database closure.
• Ensure timely database lock, data quality, and readiness for statistical analysis and regulatory submissions.
• Drive adoption of modern, scalable data management tools and workflows.
• Manage CROs and vendors delivering CDM services, ensuring compliance with timelines, budgets, and quality standards.
• Develop and monitor CDM plans, including Data Management Plans (DMPs), Data Review Plans (DRPs), and data transfer specifications.
• Resolve complex data issues, queries, and discrepancies in collaboration with clinical and statistical teams.

Cross‑Functional Collaboration

• Serve as the primary CDM representative on cross‑functional study teams.
• Partner with Biostatistics, Clinical Operations, Medical Monitoring, and Data Science colleagues to ensure data supports trial endpoints and regulatory deliverables.
• Collaborate on integration of clinical trial data with Pathos’ AI/ML platforms and real‑world data sources.

Leadership & Compliance

• Build and scale the CDM function, including hiring and mentoring staff.
• Develop SOPs, best practices, and quality frameworks to ensure compliance with GCP, ICH, and regulatory requirements.
• Contribute to portfolio‑level planning and operational strategy.

What We’re Looking For

• Bachelor’s or Master’s degree in Life Sciences, Data Management, or related field.
• 10+ years of progressive…