Clinical Digital & AI Acceleration Portfolio Manager

Job Title:

Clinical Digital & AI Acceleration Portfolio Manager

Location:

Morristown, NJ / Cambridge, MA About the job Our Team:
Sanofi is a leading bio-pharmaceutical company committed to advancing healthcare through groundbreaking research and development. Our dedicated function - Clinical Sciences & Operations (CSO) - plays a vital role in ensuring accurate and compliant clinical trial submissions and project operations, contributing to the approval of innovative therapies that transform patients' lives. Within CSO, the Modernization & Performance Office (MPO) acts as a strategic transformation engine, driving modernization, digital acceleration, and measurable value creation across clinical development.

MPO ensures that strategy, execution, and value realization are tightly connected, enabling CSO to operate faster, smarter, and  Overview: CSO Digital Transformation is a flagship, multi-year transformation program designed to fundamentally modernize Sanofi's clinical operations through the scaled adoption of digital technologies, data, and Artificial Intelligence. The portfolio spans site and patient engagement, operational acceleration (including clinical supply chains), real-time data access, and AI-enabled operations and decision support, with a strong emphasis on measurable business and patient impact.

The Clinical Digital & AI Acceleration Portfolio Manager is a senior strategic partner to the Head of Clinical Digital & AI Acceleration. Unlike a traditional PMO role, this position orchestrates the end-to-end transformation portfolio from strategy to value realization, ensuring that initiatives are prioritized, integrated, governed, and scaled in line with CSO and Sanofi enterprise objectives. This role interfaces with executive sponsors, program leaders, finance, and business capability owners to ensure that programs and projects deliver tangible outcomes, quantified value, and sustainable adoption, supported by robust digital portfolio performance intelligence, dashboards and insights.

Main Responsibilities Strategic Portfolio Alignment & Modernization:
Continuously align portfolio components with Sanofi's strategy and CSO priorities, ensuring a clear line of sight between transformation investments and business outcomes Shape and challenge the portfolio strategy by developing scenarios that support executive decision-making, trade-offs, and prioritization Identify cross-initiative synergies, reuse opportunities, and integration levers to avoid siloed digital initiatives Translate modernization ambitions (digital, data, AI) into executable, value-driven roadmaps Actively identify new modernization opportunities across clinical operations, informed by performance data, capability gaps, and emerging technologies Portfolio Governance & Operating Model Coordinate, evolve and professionalize the Initiative Portfolio Management Office (iPMO) as a strategic governance layer, not only a control mechanism Define and maintain governance standards covering value hypotheses, ROI tracking, adoption readiness, and scale-up criteria Coach and challenge program teams on business case quality, value articulation, and outcome-based delivery Ensure alignment with Digital, eDEV, and CSO innovation governance, including integration of externally incubated or "off-the-shelf" solutions Act as a modernization thought partner rather than a purely procedural PMO Portfolio Performance & Value Management:
Own the definition and consolidation of portfolio-level KPIs, including value realization, adoption, maturity, and transformation impact Monitor portfolio health using decision-grade performance intelligence (progress, risks, interdependencies, value delivery) Proactively identify risks, bottlenecks, and underperforming initiatives, and recommend corrective or reprioritization actions Ensure robust transition to business and establish and maintain a framework for visibility of transition to business and scale-up, tracking whether initiatives deliver value beyond pilot phases Produce executive-level insights and narratives linking digital transformation to tangible CSO outcomes Manage complex transformation program as needed Financial Strategy & Value Realization:
Partner with Finance and OPCM to drive disciplined investment management across the portfolio Ensure initiatives are supported by clear financial logic (ROI, cost avoidance, productivity gains, quality or cycle-time impact) Track financial performance across the lifecycle, from investment decision to realized value Support budget cycles and financial milestones with credible, evidence-based portfolio insights Strategic Resource & Capability Alignment Assess and consolidate portfolio-level resource needs, with a focus on critical capabilities rather than just capacity Optimize resource allocation across initiatives to maximize portfolio throughput and value Support vendor strategy, sourcing decisions, and contract governance in alignment with transformation…