Research Associate​/Sr Research Associate: In vivo Preclinical Research

Overview

Research Associate/Sr Research Associate:
In vivo Preclinical Research

Research Associates / Senior Research Associates will be responsible for primarily conducting in vivo experiments to evaluate efficacy of client test compounds across various rodent models with a secondary role in supporting in vitro/ex vivo lab work and aiding in staff distributed duties to support daily lab and vivarium operations. A successful candidate will have hands-on experience with in vivo animal studies and working knowledge of in vitro laboratory techniques to support in vivo studies, such as tissue culture, RNA/DNA processing, and ELISA/Western Blot.

Candidates will work closely with multidisciplinary teams to support various client and internal projects.

• Assist in the design and execution of in vivo rodent studies across various therapeutic areas with duties including animal weighing, dose administration (e.g. subQ, IP, PO, IM, retro-orbital, IV), blood and tissue collection, necropsy, oncology and functional readouts.
• Perform in vivo imaging and analysis of data in cancer models
• Proficient with cell culture techniques using various immortalized cell lines to support oncology studies is desired
• General understanding of pharmacokinetics, pharmacodynamics, and drug metabolism
• Ability to follow strict instructions on formulation of test compounds for in vivo dosing
• Analyze in vivo data independently or under minimal guidance of senior scientists
• Contribute to generation of reports for in vivo experiments or other related study presentations with guidance of senior scientists
• Work collaboratively with cross-functional teams to support department’s goals and timelines
• Aid in lab equipment maintenance and general lab support
• Maintain a safe laboratory environment by following standard operating procedures (SOP) and established IACUC protocols
• Other related duties as assigned

Required Qualifications:

• BA/BS or MS in Biology, Immunology, Biomedical Sciences, Microbiology, Virology, Pharmaceutical Sciences, Pharmacology or a related discipline
• Two or more years of laboratory experience utilizing techniques or methods required by the position or an equivalent combination of education and experience in an academic lab environment
• Recent post graduates with a desire to expand their skill set are encouraged to apply
• Must be comfortable working with rodents and animal derived tissues or fluids
• Adept at using automated instrumentation for analysis (e.g. IDEXX or HESKA machines)
• Openness to learning new methods and skills for shifting research needs based on clients
• General understanding of data analysis techniques and use of software (e.g. Microsoft Excel and Graph Pad Prism)
• Excellent organizational skills with attention to detail and ability to prioritize tasks to meet deadlines
• Strong written/verbal communication skills for assisting with writing reports, presentations, and client interactions
• Some evening and weekend/holiday hours are required
• Extensive and relevant research experience using rodent models of human disease
• Proficiency in a specialized therapeutic area such as fibrosis, virology, autoimmune disorders, immunology, and oncology
• Experience with oncology models
• Experience with in vitro/ex vivo assay development
• Hands-on knowledge of general laboratory techniques, including basic molecular or cellular biology techniques (e.g. RNA/DNA isolation, gel electrophoresis, PCR, RNASeq, bacterial culture and transformation, Western Blot, ELISA, mammalian cell culture, etc.)
• Working familiarity with cell based immunology techniques such as MSD/ELISA and FACS
• Understanding of preclinical drug development and regulatory process
• Prior experience handling small molecules/biologics for PK/PD studies

No Sponsorship will be offered. Seeking local candidates

Aragen Bioscience provides a stimulating work environment in which talented employees expand their technical skills and scientific knowledge and contribute directly to the ongoing success of the organization. The Company is located in Morgan Hill, California, at the south end of the Silicon Valley. We offer excellent salary and benefits. Aragen is an equal opportunity employer.