Principal Mechanical Engineer III; Life Sciences

Principal Mechanical Engineer III (Life Sciences)

Santa Clara, United States | Posted on 02/10/2026

Principal Mechanical Engineer III based out in Santa Clara, CA
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Job Duration: Long Term Contract (Possibility Of Extension)

Pay Rate : $85-$92/hr on W2

Company Benefits: Medical, Dental, Vision, Paid Sick leave, 401K

You will lead the design and development of next-generation DNA sequencing instrumentation. This is a hands‑on, senior‑level role focused on solving complex mechanical challenges at the core of highly integrated life science systems.

• Lead end-to-end mechanical design of complex sub‑systems, including electro‑mechanical, fluidic, pneumatic, and thermal components
• Design mechanisms for automated reagent and flow cell handling, sealing, and clamping
• Architect precision thermal control systems (heating, cooling, sensors, condensation control)
• Collaborate cross‑functionally with electrical, systems, consumables, materials, and assay teams
• Support system integration, verification, and troubleshooting as the technical owner
• Drive design reviews, manage technical trade‑offs, and deliver design documentation (CAD, drawings, specs)
• Contribute to future system architecture and technology strategy

• PhD + 5 years, MS + 10 years, or BS + 10+ years in Mechanical Engineering, Bioengineering, or related field
• Strong expertise in fluidics systems (pumps, valves, tubing, sensors)
• Proven experience in thermal management and precision temperature control
• Advanced proficiency in 3D CAD (Solid Works preferred)
• Experience with prototyping, testing, and manufacturing processes (machining, injection molding, 3D printing)
• Familiarity with Python, LabVIEW, or similar tools for device control and data acquisition

• Experience with NGS or genomics instrumentation
• Use of CFD / FEA to guide design decisions
• Demonstrated technical leadership and mentoring experience