Postdoctoral Research Associate - Hybrid Computational-Experimental Scientist in Bacterial Drug Resp

Job Description

We are seeking an interdisciplinary postdoctoral researcher to join our lab e Children's Research Hospital to develop new experimental-computational approaches for studying bacterial drug responses and phenotypic heterogeneity at single-cell resolution.

Our group integrates bacterial single-cell RNA‑seq, long‑read sequencing, functional genomics, microbiome models, and quantitative analysis to understand how pathogens adapt in hosts and respond to antimicrobial compounds. This position is ideal for someone with both computational strength and interest in experimental systems—or vice versa—who wants to grow into a scientific leader at the interface of data and biology.

• Combine experimental and computational approaches to analyze bacterial responses to antibiotics and host‑like conditions.
• Develop and apply statistical or machine‑learning methods for interpreting single‑cell and genomic datasets.
• Work closely with wet‑lab scientists to design perturbation experiments and screening strategies.
• Help build scalable platforms for linking genotype, cell state, and drug response.
• Contribute to manuscripts and grant proposals in high‑impact journals.
• Participate in mentoring and shaping the lab's interdisciplinary culture.

• Has a PhD in computational biology, microbiology, systems biology, engineering, physics, CS, or a related field.
• Has strength in either experimental microbiology or data analysis, and strong interest in growing in the other direction.
• Enjoys working in collaborative, fast‑moving research environments.
• Is motivated to develop new methods and biological insights in parallel.

• Experience with bacterial genetics, functional genomics, or drug‑response assays.
• Familiarity with scRNA‑seq, genomics, or multimodal datasets.
• Training in statistics, modeling, or machine learning.
• Interest in building experimental platforms or screening systems.

St. Jude is an Equal Opportunity Employer.

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative e via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St.

Jude.

This role is designed for a hybrid scientist who wants to help define a next‑generation research program at the intersection of microbiology, genomics, and quantitative biology.