Lead Researcher - Brain Organoid Biology Pediatric Neurological Disease Research

The Lead Researcher performs a variety of basic laboratory research tasks determined by the field and scope of the particular research project/study. Also, performs tasks related to the research project independently, but within specific guidelines which are subject to review by supervisor and/or other research staff.

St. Jude Children’s Research Hospital has established an expansive initiative in translational neuroscience with a mission to understand and treat catastrophic childhood neurological disease. This new initiative integrates basic and clinical neuroscience and partners with industry and foundations to develop and implement novel therapies. A key component of this is the Center for Pediatric Neurological Disease Research (CPNDR). Principal Investigators in CPNDR employ innovative laboratory-based research programs using cutting-edge approaches in molecular, genetic, biochemical, biophysical, cellular anatomical, and behavioral approaches to elucidate disease mechanisms and test therapeutic strategies relevant to understanding and treating pediatric neurological disease.

• CPNDR is currently recruiting for a Lead Researcher for the brain organoid core, which provides resources and advice to support researchers working on pediatric neurological disease pathogenesis and treatment.
• The successful recruit will be experienced in general neural cell culturing methodology and in the generation of iPSC-derived brain organoids.
• They will work closely with the Brain Organoid Core Director to support brain organoid production and research, serving CPNDR investigators and other neuroscience researchers e.
• The organoid resource is tasked with generating high-quality brain organoids such as forebrain, thalamic, cerebellar, and midbrain organoids.
• The core also provides guidance in the development and execution of new and existing techniques and procedures related to organoid generation, maintenance and usage.
• They will engage in projects focused on basic and translational research, enabling investigators to tackle diverse scientific questions.
• Strong interpersonal skills and proficiency in scientific communication and record keeping are also required for this position.

• Develop and perform procedures using established or modified techniques/protocols
• Implement new but established protocols without individual training
• Troubleshoot experiments and identify anomalies in own data
• Consistently monitors current literature and trends within field
• Accurately record experimental procedures and data
• Prepare and report results/data leading to posters, presentations, or publications
• Provide guidance to less-experienced team members
• Perform other duties as assigned to meet the goals and objectives of the department and the institution.
• Maintain regular and predictable attendance.

• Bachelor’s degree in a relevant scientific area is required

• 5+ years of research experience is required with a Bachelor's degree
• 3+ years of experience is required with a Master’s degree
• No prior experience required with a PhD
• Strong knowledge and experience in understanding and application of underlying principles related to the techniques being performed
• Experience in R&D methods and processes in a lab setting, and execution of research projects for the laboratory preferred
• Proven performance in earlier role/comparable role

When you work e, you’ll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth, you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier.

Join us and you’ll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a “Best Place to Work.”

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