PhD Studentship – Bioprocess: Harnessing Biocatalysis Toward -Generation Nucleoside Triphos

PhD Studentship – Bioprocess:
Harnessing Biocatalysis Toward Next-Generation Nucleoside Triphosphates

University of Manchester
Manchester, United Kingdom

This fully funded PhD studentship at The University of Manchester’s Department of Chemistry offers a unique opportunity to contribute to pioneering research in biocatalysis and sustainable bioprocess development
. The project focuses on the design and optimisation of enzymatic pathways for the production of nucleoside triphosphates
, key building blocks for DNA and RNA synthesis with applications in pharmaceuticals, diagnostics, and synthetic biology. The research aims to develop efficient, scalable, and environmentally friendly processes leveraging biocatalytic strategies
, mechanistic enzyme understanding, and modern bioprocess engineering. Students will gain experience in molecular biology, enzymology, fermentation, process optimisation, and analytical chemistry, within a collaborative, interdisciplinary environment that bridges academia and industry.

Applicants should hold, or expect to obtain, a first-class honours degree (or equivalent) or a good 2:1 in Chemistry, Biochemistry, Chemical Engineering, Biotechnology, or a closely related discipline
. Strong academic performance and a demonstrable interest in enzymology, molecular biology, and sustainable bioprocessing are essential.

The ideal candidate will have practical experience or strong interest in laboratory techniques such as enzyme assays, recombinant protein expression, purification methods, chromatography, and analytical characterization. Familiarity with bioprocess development principles, experimental design, and data analysis will support success in the project. Creativity, attention to detail, and the ability to work independently and collaboratively within a multidisciplinary team are essential.

The studentship includes full tuition fee coverage and an annual tax-free stipend at the UKRI standard rate, supporting the researcher throughout the four-year PhD programme.

Applications close on 17 March 2026.