Research Associate in Neurovascular Coupling

This is an outstanding opportunity for a Research Associate, with a background in imaging the cerebral vasculature in mouse models of Alzheimer’s disease, to work within the Brain Inflammation and Microvascular@Manchester groups under the supervision of Dr Kira Shaw and Dr Ingo Schiessl. The post holder will be based in the Division of Neuroscience.

The candidate will support the aims of investigating the effects of menopause on neurovascular health using preclinical mouse models of Alzheimer’s disease (AD) and AD risk, funded by the Wellcome Trust. This innovative project will involve the use of in vivo imaging approaches (e.g. multi‑photon microscopy and optical imaging spectroscopy) to assess neuronal and vascular function in the hippocampus and neocortex of awake mice.

Cognitive function will be assessed using established behavioural tests. Post‑mortem analysis will include immunohistochemistry and RNA sequencing to identify candidate treatments targeting menopause‑sensitive vasodilation pathways.

This position offers an ideal opportunity for an enthusiastic, well‑motivated individual to work as part of a sociable multi‑disciplinary team. The ideal candidate will have excellent preclinical imaging skills, and will be able to work with minimal supervision. Experience of imaging the cerebral vasculature in vivo is essential for the position.

Successful candidates may be subject to pre‑employment screening carried out on our behalf by a third party. The offer of employment will be dependent on the successful candidate passing that screening. Whilst you will be required to provide express consent at a later stage, by continuing with your application now you acknowledge that you are aware that such screening will take place, and agree to take part in the process.

• Fantastic market leading Pension scheme
• Excellent employee health and wellbeing services including an Employee Assistance Programme
• Exceptional starting annual leave entitlement, plus bank holidays
• Additional paid closure over the Christmas period
• Local and national discounts at a range of major retailers

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

Name:
Kira Shaw
Email:

Name:
Ingo Schiessl
Email: in

General enquiries:
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This vacancy will close for applications at midnight on the closing date.

Please see the link below for the Further Particulars document which contains the person specification criteria.