Discovery DMPK Lead

Discovery DMPK Lead (m/f/d) – Grünthal Group

Professional | Permanent | Full-time | Hybrid

In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state‑of‑the‑art Research & Development environment, developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain.

• DMPK representative on project teams influencing project progression from target validation through to candidate selection and into preclinical development
• For small molecule and oligonucleotide projects, lead the scientific and operational design, conduct, implementation, and analysis of DMPK, ADME and PKPD studies to support the progression of discovery projects towards candidate selection and preclinical development using state‑of‑the‑art computational, in vitro and in vivo technologies
• Align with Medicinal Chemistry, Pharmacology, Genetic Medicines, Pharmaceutical Sciences and Clinical to ensure human PK, PKPD and dose predictions are undertaken to aid project decision making from target validation through to candidate selection for all modalities
• Align with non‑clinical safety to integrate PK and metabolism understanding into safety risk assessment, interpretation and quantitation/prediction of therapeutic margin of candidate molecules
• Engage with Development DMPK and Clinicians to ensure human PK, PKPD, ADME and DDI predictions of candidate molecules are sufficiently robust to be utilised effectively in early clinical study design and dose selection
• Engage with CROs and external consultants regarding conduct and interpretation of both discovery and preclinical development DMPK studies
• Keep abreast of DMPK science through literature and conferences and look to publish work where possible

• Educated to degree or PhD level in biological or pharmacological sciences or related field with at least several years experience gained working in DMPK discipline in industry as a DMPK project representative on discovery and development projects
• For small molecules, expert technical knowledge of ADME/DMPK principles particularly in drug discovery and good understanding of their relationship to drug design, pharmacology and PKPD
• For oligonucleotides, sound understanding of DMPK and PKPD principles for these modalities and preferably some experience of oligonucleotide projects
• Ability to design, initiate and oversee discovery DMPK/ADME studies at CROs with timely delivery of data and interpretation that drives DMPK optimisation
• Track record of interpretation and reporting of DMPK studies to support decision making
• Experienced in pharmacokinetic analysis with experience in use of software such as Phoenix/Win Non Lin  PK
• Excellent written and communication skills
• Demonstrated ability to work in a matrix environment, multi‑task, meet deadlines and deal with evolving priorities

DMPK sciences plays a crucial role at the interface between preclinical and clinical development. At Grünthal we are at an exciting phase of innovation of small molecules and genetic medicines for Pain R&D. Come join us in DMPK on this journey.

Paul Morgan, the Hiring Manager