Advisor​/Senior Advisor-Bioanalytical Research

Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.

The Investigational ADME, Toxicology, and Bioanalytical Research organization at Lilly is seeking an experienced scientist to lead the Bioanalytical Research (BAR) team located at our Louisville, CO facility. The research focus of this team is developing and employing mass spectrometric applications to investigate the ADME properties of radio-ligand therapeutics (RLTs), Antibody-Drug Conjugates (ADCs), and small molecule xenobiotics to discover and characterize optimal drug candidates to progress to clinical development.

• Building and leading an innovative bioanalytical research team, with associated analytical strategies, to deliver pharmacokinetic (PK), biotransformation (BioT), and biodistribution (BioD) data to program teams developing RLTs, ADCs, or small molecule drugs.
• The supervision and career development of junior laboratory scientists and scientific contractors.
• The management, prioritization, and delivery of bioanalytical support to a large and diverse spectrum of drug program teams.
• The technical development and implementation of mass spectrometric approaches (QQQ, high-resolution, and ICP-MS) to investigate the PK, BioT, and BioD of novel drug candidates in pre-clinical animal models.
• Serving as the bioanalytical lead on discovery programs, partnering closely with cross‑functional teams including ADME, Toxicology, Chemistry, therapeutic areas (Oncology, e.g.), and Biotechnology Discovery Research.
• Interpreting innovative MS datasets and presenting clear, actionable scientific insights to program teams and ADME Project Leaders.

• MS in chemistry, biochemistry, engineering, pharmacology, or an associated field with 10+ years of industry experience
• Hands‑on experience in the application of LC-MS for the bioanalysis of ADCs or small molecule drugs. This includes experience with advanced sample preparation techniques such as LLE, SPE, microwave digestion, and/or immunoaffinity capture approaches.
• Excellent scientific communication, problem‑solving, and project‑level collaboration skills.

• A PhD in chemistry, biochemistry, engineering, pharmacology, or an associated field with 3+ years of relevant experience
• Experience supervising laboratory staff.
• Expertise with MS‑informatics tools such as Proteome Discoverer, Protein Metrics, DAR workflows, Mass Meta Site , and Biopharma Finder.
• Knowledge of drug ADME principles.
• Hands-on experience developing and implementing ICP-MS assays to study RLTs or imaging agents.
• Experience developing and implementing automation for in vivo or high-throughput in vitro metabolism screens is highly desirable (Tecan, Hamilton, King Fisher, e.g.).

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