Scientific​/Sr Scientific Lead, Bioconjugation

Scientific/Sr Scientific Lead, Bioconjugation page is loaded## Scientific/Sr Scientific Lead, Bioconjugation locations:
US:
Louisville CO Site 3time type:
Full time posted on:
Posted Todayjob requisition :
R-99056

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.
** JOB DESCRIPTION
**** Position:
Scientific/Sr Scientific Lead, Bioconjugation, Large Molecule Discovery
***
* Location:

Louisville****, CO, USA
**** Overview:
** At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.
*
* Position Summary:

** Lilly Oncology’s Large Molecule Discovery team is looking for a Scientific Lead or Senior Scientific Lead in Chemistry/Biochemistry to support our growing biologics and ADC portfolio. This role will provide scientific leadership in developing bioconjugation technologies, downstream biochemical assays to improve ADC linker-payload design and enhance ADC biological and pharmacologic performance. The successful candidate will bring deep technical expertise in ADC design and execution, demonstrate strong experimental rigor, and act as a collaborative scientific partner across discovery teams.

This position requires a hands-on scientist who can independently execute complex studies while contributing to broader platform strategy, intellectual property, and innovation. The individual will thrive in a highly interactive, fast-paced research environment and will be expected to influence project direction through high-quality data, clear scientific reasoning, and effective communication.
** Responsibilities:
*** Prepare, purify, and characterize the high-quality antibody-conjugates (ADCs, ARCs, DACs etc.) with a high degree of independence in support of discovery and development of programs.
* Work with the linker-technology and medicinal chemistry teams to design and optimize the linker-payload and its bioconjugation chemistry.
* Apply organic and bioconjugation chemistry principles to guide linker-payload SAR and improve stability, potency, and develop ability.
* Implement state of the art bioconjugation technologies (cysteine, lysine, site-specific and other) and utilizing novel chemistries to generate bioconjugates.
* Develop purification strategies (up to 200 mg) with affinity, ion-exchange, hydrophobic interaction, size exclusion, and tangential flow filtration.
* Perform comprehensive ADC characterization using UV-Vis, SEC, HIC, RP-HPLC, IEX, cIEF, and LC-MS.
* Engage with multidisciplinary teams across chemistry, biology, pharmacology, and CMC to design and interpret experiments.
* Maintain thorough documentation of experimental procedures in electronic notebook or database, writing of reports and technical documents.
* Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences.
* Demonstrated record of scientific accomplishments and publications.
* Present periodic updates and reports to management team.
* Contribute to the long-term strategies for innovative solutions and intellectual property for securing FTO for Lilly.
* Maintain a safe, pleasant, and efficient working environment.
** Basic Requirements**:
* PhD in chemistry, biochemistry, or other related scientific discipline.
* Minimum 2-4+ years of independent, hands-on laboratory experience in an industrial or equivalent research setting (including post doc experience).
** Additional Preferences:
*** Experience…