Lead Biosensor Research Scientist

About Level Zero

Level Zero is pioneering next‑generation biosensor technology for precise, real‑time monitoring of critical endocrine biomarkers. Recognised as one of the top 20 startups across all categories worldwide at Tech Crunch Disrupt 2024—and backed by top‑tier organisations like SOSV and Entrepreneur First—we’re pushing the boundaries of biochemistry and nanotechnology to revolutionise personalised health.

Founded by two seasoned engineers, we bring extensive experience in R&D, technical innovation, and commercial strategy to transform the way people monitor their health. Our mission is bold: to revolutionise health management by delivering clinical‑grade data directly to individuals, wherever they are.

We’re seeking driven innovators to join us in pushing the boundaries of biosensing and health tech, making personalised health monitoring a reality for everyone. To achieve this ambitious vision, we’re assembling the best team in the world—dedicated to turning cutting‑edge science into life‑changing, real‑world solutions.

We are excited to welcome a lead biosensor scientist with a strong background in lateral flow assay R&D, scale‑up and experience in working with aptamers to join our rapidly growing start‑up. The ideal candidate is expected to be proficient in bench and wet chemistry techniques. Moreover, they should have proven knowledge and experience in assay development and nanoparticle surface modifications (biomolecules, small molecules).

It is essential for the candidate to have extensive experience in aptamer‑based and antibody‑based nanogold colourimetric biosensor R&D, including the designs, operation principles, troubleshooting, and analysis.

This is a full‑time, in‑person role primarily based in London.

• Lead the development and the scale‑up of LFA components and assay designs.
• Perform conjugation procedures between nanoparticles, aptamers, proteins, and small molecules, as well as the optimisation of such procedures for meeting performance parameters in assays.
• Validate aptamer biorecognition and the performance of functional gold nanostructures in different biological medium using colourimetric assays.
• Fabricate biosensor devices: working on prototype iteration all the way to mass manufacture.
• Analyse and organise raw experimental data as technical reports.
• Work closely with the R&D leadership to optimise progress towards R&D milestones.
• Attend R&D‑related trainings and seminars for continuous updates on the latest trend in hormone sensing technologies.

• A Ph.D. degree in chemistry, material science, biomedical engineering, bionanotechnology or related discipline, with a focus in aptamer nanobiosensors. At least 4 years of industry experience.

• Proven knowledge and experience in lateral flow assay development with experience launching assays to market.
• Proficiency in wet chemistry laboratory techniques, including nanomaterial characterisations and liquid‑handling techniques.
• Experience and a deep understanding in gold nanostructures: their use in biosensors, synthesis, and the opportunities for surface modifications.
• Strong experience in assay development, particularly in unlocking key hurdles (non‑specific binding, signal‑to‑noise enhancement, optimising assay binding conditions).
• Expertise in the R&D of colourimetric nanobiosensors and aptamer biorecognition.
• Understanding of aptamers and small molecules handling skills.
• Experience in leading a small team.

• Experience in gel electrophoresis and blotting methods.
• Experience in metallic nanostructure analytical skill: ICP‑MS or ICP‑OES.

• We value culture as much as we value technical expertise, creating an environment that’s equal parts collaboration, curiosity, and fun.

We’re a fast‑paced, mission‑driven young team on a quest to make a lasting impact, fueled by uncompromising integrity, unwavering support for one another, and the thrill of exploring uncharted territories. Our passion for excellence drives everything we do, and we welcome individuals who share our commitment to shaping the future.

• You live and breathe integrity,…