Cognitive Disorders Clinical Research Fellow

A Vacancy at University College London Hospitals NHS Foundation Trust
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University College London Hospitals NHS Foundation Trust invites candidates to apply for an exciting opportunity as a full‑time Clinical Research Fellow post based at the Dementia Research Centre, at the National Hospital for Neurology and Neurosurgery.

We are looking for an enthusiastic, committed individual with excellent communication and clinical skills to join our clinical research team at the Dementia Research Centre. This centre is internationally renowned for performing groundbreaking research into dementia, with particular focus on familial dementias and translational research. Early‑phase clinical trials are a high priority: in particular, looking for disease‑modification therapies using cutting‑edge methods such as immunotherapy and gene silencing.

In addition to interventional trials, we run longitudinal cohort studies in normal ageing, genetic FTD (GENFI) and AD (DIAN) looking for biomarkers of early disease and to better understand the pathophysiology. We work closely with basic science colleagues at the Dementia Research Institute and collaborate on multiple translational projects.

This post would suit someone who is looking to enhance their understanding of research in dementia without initial commitment to a PhD.

• Applicants must have a relevant medical degree and be fully registered with the GMC by the expected start date (ASAP). A good knowledge of neurology and an interest in research are essential.

The successful candidate will be primarily involved in clinical trials as part of the DRC clinical trials unit led by Cath Mummery. This is a multidisciplinary team with extensive experience in first‑in‑human, highly complex trials. The candidate will also have the opportunity to take part in the cognitive disorders clinics and other educational opportunities at the DRC, and to get involved in other aspects of research.

• Work closely and co‑operatively with other members of the group to deliver the highest standards of clinical care to patients and study participants.
• Collaborate with other members of the DRC and external collaborators and sponsors to ensure that the highest quality clinical data are collected.
• Work with the clinical trials team and LWENC staff to ensure delivery to target in drug trials, recruiting and screening potential research subjects and maintaining clinical and research records.
• Receive training in intrathecal administration of gene‑silencing therapies and administer them as part of trial protocol.
• Treat infusion‑related reactions and other medical emergencies; ideally hold an advanced life‑support certificate.
• Assist with a cognitive clinic a week under consultant neurologist supervision.
• Attend patient support groups and be involved in community engagement as required.
• Analyse imaging and other data sets and contribute to scientific writing.
• Assist in preparing materials (e.g., slides, diagrams) for presentation and/or publication by members of the DRC.
• Assist in the development of the dementia research programme, promoting ongoing studies, monitoring recruitment rates and encouraging referrals.
• Support the recruitment team in screening the right patient for the right study and manage disappointing outcomes for patients, such as screen fails or early trial terminations.
• Provide teaching on topics related to the post holder’s work as requested by the line manager.
• Contribute to the department’s multidisciplinary research projects within the strategy.
• Prepare and analyse data for publications for dissemination of research and for presentation at international conferences as well as internal meetings at UCL, and meetings with external collaborators.
• Ensure the highest standard of record keeping, maintaining accurate, complete, and up‑to‑date records.
• Ensure confidentiality is maintained as applicable.
• Attend and contribute to departmental, institutional, and other meetings as appropriate.
• Act at all times in accordance with the highest professional standards and ensure these are maintained in the delivery of all aspects of research.
• All staff are required to act professionally, co‑operatively, and flexibly in line with the requirements of the post.

Additional information regarding the main responsibilities of this role can be found in the attached Job Description.

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