Senior Research Associate , In Vivo - Bone​/Fibrotic Disease Unit

Senior Research Associate I, In Vivo - Bone/Fibrotic Disease

Lexington, Massachusetts, United States

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue.

We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.

Keros Therapeutics is a public, clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel treatments for patients suffering from neuromusculoskeletal disorders and other rare diseases with high unmet medical need. We are a leader in understanding the role of the transforming growth factor-beta, or TGF-ß, family of proteins, which are master regulators of red blood cell and platelet production as well as of the growth, repair and maintenance of muscle and bone.

We have leveraged this understanding and developed a discovery approach to generate large and small molecules to address diseases of these tissues. Targeting TGF-ß signaling pathways has been clinically proven to elicit robust changes in blood cells, muscle, and bone, which we believe provides a precedent and strong rationale for our strategy.

• Design, execute and manage complex experiments and research projects with minimal supervision
• Perform basic animal handling, including dosing, (IP, IV, SC, PO, IT, OA), blood and tissue collection, necropsy, and small animal surgeries.
• Ex vivo processing of tissues for further characterization, including RNA isolation for qPCR, protein lysates for Western blots or ELISA, single cell suspensions for flow cytometry and cryo-sectioning tissues for immunohistochemistry
• Small transgenic rodent colony management, including sex identification, setting up breeding pairs/trios, identification of pregnant dams, tissue sample collection (e.g., ear punch or tail snip) and genotyping.
• Analyze and interpret experimental data, troubleshoot technical challenges and optimize protocols.
• Collaborate closely with team members to align experimental work with broader research goals.
• Contribute to the drafting of reports and presentations for internal and external communication, including publications and regulatory documents.
• Mentor and train junior research associates/co-ops providing guidance on experimental design, data analysis and best laboratory practices.
• Ensure laboratory operations comply with all safety regulations, standard operating procedures (SOPs) and quality control standards.
• Contribute to the maintenance, calibration, and use of laboratory equipment and efficient operation of the laboratory.
• Stay current with the latest scientific literature and technological advancements, incorporating new knowledge into research activities, particularly in preclinical in vivo models.
• Participate and contribute to scientific discussions on project direction and objectives.
• Maintain detailed records in electronic lab notebook (ELN)

• Experience working with and developing rodent disease and mechanistic models and running pharmacokinetic and pharmacodynamic experiments including dosing, (IP, IV, SC, PO, IT, OA), blood and tissue collection, necropsy, and small animal surgeries.
• Extensive experience with a wide range of wet laboratory techniques, including qPCR, Western blotting, ELISA, flow cytometry and immunohistochemistry.
• Strong problem-solving skills, with a track record of successfully troubleshooting and optimizing experimental protocols.
• Excellent data analysis skills, with proficiency in data analysis software and experience with statistical analysis.
• Proven ability to mentor and train junior team members, fostering a collaborative and…