Principal Research Associate, Antibody & Protein Engineering

Company Overview

Adimab is the leading technology provider for therapeutic antibody drug discovery, focusing solely on our partnerships without pursuing an internal product pipeline. Since 2009, we have partnered with over 140 pharmaceutical and biotechnology companies, generating more than 650 therapeutic programs, of which more than 85 have entered clinical trials.

Principal Research Associate, Antibody & Protein Engineering

We are seeking an experienced, self‑motivated, and enthusiastic protein engineer to join our Platform Technologies team. The Principal Research Associate will work in a small, collaborative team to execute and advance Adimab’s platform for the discovery and optimization of protein‑based therapeutics. The successful candidate will have prior experience in molecular biology, protein engineering, and flow cytometry, with preferred experience in display technologies (yeast, phage or mammalian).

• Design and execute protein engineering experiments
• Construct yeast display libraries and perform FACS selections
• Perform protein and DNA sequence and basic 3D structural analysis
• Collect, organize, and interpret antibody characterization data
• Collaborate effectively with colleagues and external partners

• B.S. or equivalent practical experience, with training in molecular biology, chemical engineering, or biochemistry
• At least 2 years of lab experience in an academic or industry setting
• Knowledge of molecular biology, protein engineering, structural biology, and/or flow cytometry
• Meticulous approach to benchwork and data analysis

• B.S. or M.S. with training in molecular biology, chemical engineering, biochemistry, or a related field
• 4+ years of relevant industry or research experience
• Strong foundation in molecular biology, protein engineering, and flow cytometry
• Experience with protein display technologies (yeast, bacterial and/or ribosomal) desired
• Experience with protein sequence analysis and next‑generation sequencing workflows desired
• Experience with protein structural analysis or computational design methods desired
• Demonstrated ability to evaluate, interpret, and present scientific data clearly
• Self‑directed with a proven track record of executing independently at the bench and driving projects to completion
• Highly organized with the ability to manage multiple projects simultaneously
• Adaptable and productive in a fast‑paced environment
• Communicates effectively and openly with colleagues and supervisors
• Resourceful with outstanding problem‑solving skills
• Quantitatively proficient, including demonstrated competency in Microsoft Excel

Our integrated antibody discovery and engineering platform provides unprecedented speed from antigen to purified, full‑length human IgGs with exquisite specificity and biophysical behavior. We offer fundamental advantages by delivering diverse panels of antibodies that meet the most demanding standards for affinity, epitope specificity, species cross‑reactivity, and develop ability. We enable our partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.

As a profitable privately‑held biotech company, we take a long‑term view on value creation and make substantial investments in technology development, research, and our people. We offer individually tailored compensation packages comprised of a competitive salary, meaningful equity, a 2:1 401(k) match, and comprehensive health care benefits.

Located in New Hampshire’s beautiful Upper Connecticut River Valley, we are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated in an area that is renowned for its premier skiing, hiking, kayaking, and biking.