Master Thesis Cell Biology at EPFL

Master Thesis offer on Cell Biology at EPFL, Switzerland (paid)

The Cell Dynamics and Fragmentation Laboratory is a newly established research group at EPFL led by Juan Manuel Garcia-Arcos, hosted at the unit of Pierre Gönczy. Our research aims to uncover how cells shed large biologically active fragments. This phenomenon occurs in cancer progression, immune cell behavior, and developmental processes, yet the underlying mechanical and molecular principles remain largely unexplored.

Objective: establish and characterize a panel of primary cells and cell lines that are likely to fragment in vivo. Evaluate their behavior under mechanical confinement and shear stress in vitro and create a reference dataset of fragmentation propensity across cell types.

Approaches: culture and differentiation of primary cells (e.g., megakaryocytes, immune progenitors), maintenance of cancer and epithelial cell lines, standardized confinement and flow assays, live imaging, quantitative screening, construction of a cell fragmentation database.

Ideal for students in:
Life Sciences, Medicine, Bioengineering.