Senior Scientist

Overview

Title:

Senior Scientist – Cell-Based Drug Screening & in Cell Compound Characterization

Company: SEED Therapeutics ()

Lab

Location:

411 Swedeland Road, King of Prussia, PA

Department:
Research and Development

Group:
Cell based drug screening and in cell compound characterization

Who We Are…

SEED Therapeutics () is pioneering the science of improving human health by creating molecular glues: novel therapeutics that degrade disease-causing proteins that have heretofore remained undruggable. Through ongoing collaborations with world-leading academic experts in the field, and in partnership with seasoned drug development and commercialization experts, SEED Therapeutics is establishing a growing pipeline of exciting drug candidates on a path to clinical and commercial success.

Our mission is to positively impact human health by creating novel protein degradation therapeutics for the treatment of severe diseases with limited impactful therapeutic options.

Our Work Place..

Is a state-of-the-art research facility in King of Prussia, PA. Located in the Pennsylvania-New Jersey Pharma corridor, this site is within driving distance of world-class shopping, dining, and educational institutions. The SEED research laboratory at Discovery Labs is an innovation engine that drives our molecular glue discovery and development efforts.

A scientist to join cell-based drug screening and in vitro characterization group to conduct proof-of-concept, validation, and compound screening studies to support multiple molecular glue discovery programs. You will be passionate about scientific discovery, undeterred by bold challenges, and enjoy working as a team to develop novel molecular glues. You should be highly organized, a critical thinker, adaptable to changing priorities, and possess a strong ability to collaborate effectively with teams of diverse backgrounds.

• This is a lab-based role to implement biochemical and cellular assays for drug screening, hit/lead characterization, and mechanism studies.
• Design, optimize and perform a variety of cell based functional assays including but not limited to cell proliferation, Western Blotting, ELISA, in-cell proximity assays to evaluate the molecular glue hits.
• Generate transient or Stable cell lines by utilizing state of art technologies to knock in or knock out/down target genes.
• Design, optimize, and execute diverse, complementary cellular assays and molecular biology techniques, including multi-omics analysis and genetic perturbation (knock-in/knock-down/knock-out), to elucidate the Mechanism of Action (MoA) of molecular glues.
• Analyze, interpret, summarize, and present research findings at project team meetings and leadership meetings.
• Ensure that all projects are delivered on time, within scope and within budget.
• Collaborate across the company to advance Seed’s drug discovery platforms and drug candidate.
• Maintain meticulous records to capture the data and value created internally and externally.
• Maintain a safe, clean and organized work environment free of safety hazards.
• Project leadership and CRO management as needed.
• Prepare study reports, manuscripts, patent applications and SOPs for all laboratory work performed repeatedly.

• Ph.D. in Biology, Pharmaceutical Sciences or related fields with at least 5 years of cell culturing experience, and at least 3 years’ experience of testing compound activity in cell-based assays; experience in TPD field is a plus.
• Strong molecular and cellular biology background and hands-on experience with developing, optimizing, and troubleshooting a broad spectrum of biochemical and cellular assays, including but not limited to cell proliferation, Western Blotting, ELISA, TR-FRET, Alpha
  
  LISA and flow cytometry.
• Hands-on experience in mammalian cell line transfection methods such as lipofectamine, electroporation and lentivirus infection. Familiarity with siRNA/CRISPR technology to knock in and knock out/down genes.
• Proven ability to multitask effectively and collaborate seamlessly within a fast-paced laboratory environment is required.
• Experience in operating under SOPs, maintaining excellent documentation of all work, including…