Statistical Programmer | AAVantgarde Bio

GT was founded in 2019 by a former Apple, Nest, and Google executive.GT’s mission is to connect the world’s best talent with product careers offered by high-growth companies in the UK, USA, Canada, Germany, and the Netherlands.

On behalf of
AAVantgarde Bio
, GT is looking for Senior Statistical Programmer (Consultant) to support an advanced ophthalmology.

AAVantgarde Bio is an international clinical-stage biotechnology company developing next-generation gene therapies for inherited retinal diseases. The company has created two proprietary technologies that enable the delivery of large genes into human cells, overcoming one of the major limitations of traditional gene therapy approaches. These platforms are already being validated in clinical trials, with the potential to expand into multiple disease areas beyond ophthalmology.

Headquartered in Milan, AAVantgarde operates with a growing international team and a strong focus on translating advanced science into real patient impact. The company was founded by Professor Alberto Auricchio, a globally recognised pioneer in gene therapy.

• Founded
  : 2021
• Series B startup

We are scaling a next-generation biometrics function to support a rapidly advancing ophthalmology pipeline where speed, data quality, and scientific insight directly determine programme success.

This is a role for a self-driven Statistical Programmer who proactively owns their deliverables end-to-end and consistently delivers work of exceptional quality—often under tight, business-critical timelines.

This role suits someone who brings technical mastery in SAS and strategic awareness. You will anticipate analytical needs before they arise, shape programming frameworks that scale with our development ambitions, and ensure that clinical and imaging data are transformed into high-impact evidence packages for regulatory interactions, governance meetings, and board-level decisions.

Clinical Programming & Analysis Delivery

• Develop, validate, and maintain high-quality SAS programs for SDTM, ADaM, TLFs, exploratory endpoints, and ophthalmology-specific analyses.
• Apply deep SAS expertise to build and maintain robust, reusable macro libraries, driving cross-study standardisation and reducing cycle times.
• Implement standardised processes, templates, and QC frameworks to deliver consistent, audit-ready outputs.
• Own key analysis deliverables from conception through execution, ensuring accuracy, traceability, and readiness for high-visibility use.
• Flex outside standard hours when necessary to meet time-critical milestones (IDMC packages, rapid eligibility decisions, regulatory responses).
• Independently identify analysis gaps, data risks, and upcoming needs—proactively initiating work before requests surface.

Data Standards, Submission Readiness & Quality Governance

• Deliver SDTM and ADaM datasets that meet global regulatory standards for imaging-rich ophthalmology trials.
• Develop define.xml, reviewer’s guides, metadata, and traceability documentation with meticulous attention to detail.
• Drive macro- and process-level standardisation across programmes to ensure efficiency, reproducibility, and seamless auditability.
• Anticipate regulatory and clinical questions and design programming strategies that support defensible, submission-ready analyses.
• Ensure programming frameworks can evolve with the complexity of multimodal imaging and reading-centre data.

Strategic Collaboration & Decision Support

• Transform clinical and imaging data into crisp, decision-ready insights for senior leadership, governance committees, and board presentations.
• Partner closely with statisticians, clinical scientists, imaging vendors, and medical teams to ensure programming aligns with scientific objectives.
• Operate as a strategic contributor—not just an executor—proactively recommending analyses, visualisations, and data structures that support programme acceleration.
• Communicate technical topics clearly and confidently, tailoring the narrative to scientific, clinical, and executive audiences.

Innovation, Automation & Continuous Improvement

• Expand automation through SAS macro frameworks and version-controlled…