Research Fellow-PC-Gastroenterology

Overview

The Gubatan Lab at Mayo Clinic Florida is seeking a postdoctoral research fellow to support a basic and translational research program in inflammatory bowel disease (IBD). The lab focuses on mechanisms of IBD pathogenesis, therapy resistance, and host immune–microbiome interactions using patient‑derived samples and established mouse models.

• Provide research in immunology, bioinformatics, systems biology, or related disciplines with experience in multi‑omics and translational research.
• Engage in ongoing projects including: spatial transcriptomics to investigate therapy failure in ulcerative colitis (JAK inhibitors) and small‑bowel Crohn’s disease (anti‑IL23 therapies); peripheral blood scRNA‑seq, immune repertoire (TCR/BCR) sequencing, and machine learning to classify IBD and predict therapeutic response; fibroblast–immune cell interactions in IBD; regulation of IgA/IgG binding to gut microbiota; CX3CR1⁺ regulatory B cells and host–microbiome interactions.
• Apply single‑cell and spatial transcriptomics, shotgun metagenomics, IgA/IgG‑Seq, immune repertoire profiling, computational methods, cell culture, and mouse models.
• Present data, prepare manuscripts, and support grant submissions. Leadership and mentoring experience is beneficial.

• Preferred qualifications include proficiency in molecular biology (DNA/RNA isolation, qPCR, western blot, ELISA)
• Immunology techniques (flow cytometry, cell isolation, immunohistochemistry)
• Cell culture and co‑culture systems
• Mouse handling (genotyping, injections, drug administration, tissue harvesting)
• R and/or Python for bioinformatic analysis (transcriptomics, metagenomics, etc.)
• Microbiology experience is a plus

Mentor laboratory technicians, visiting scholars, and trainees in experimental design and data analysis.

• Ph.D. or M.D./Ph.D. in Immunology, Biochemistry, Molecular/Cell Biology, Microbiology, Bioinformatics, Systems Biology, or a related field.
• Prior postdoctoral experience is helpful but not required. Strong background in multi‑omics is highly preferred.
• Excellent analytical, written, and verbal communication skills.

Preferred qualifications include proficiency in:

• Molecular biology (DNA/RNA isolation, qPCR, western blot, ELISA)
• Immunology techniques (flow cytometry, cell isolation, immunohistochemistry)
• Cell culture and co‑culture systems
• Mouse handling (genotyping, injections, drug administration, tissue harvesting)
• R and/or Python for bioinformatic analysis (transcriptomics, metagenomics, etc.)
• Microbiology experience is a plus

Interested candidates should submit a CV or NIH Biosketch and reference contact information or support letters from previous research mentors to Dr. John Gubatan nmark

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

• Medical:
  Multiple plan options.
• Dental:
  Delta Dental or reimbursement account for flexible coverage.
• Vision:
  Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement:
  Competitive retirement package to secure your future.

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives.

Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

• Job Identification 374672
• Job Category Research
• Posting Date 01/21/2026, 07:52 PM
• Apply Before 06/30/2026, 04:00 AM
• Job Schedule Full time
• Locations 32224
• Benefits Eligible Yes
• Compensation Detail $64,079 - $74,963 / year;
  Education, experience and tenure may be considered along with internal equity when job offers are extended.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Mayo Clinic participates in E-Verify and may provide the Social Security Administration with information from each new employee's Form I-9 to confirm work authorization.