Senior Scientist , Cell​/Molecular Biology

Company Description

Abb Vie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address tomorrow’s medical challenges. Abb Vie operates across key therapeutic areas and provides products and services in its Allergan Aesthetics portfolio.

The Toxins group within the Product Development, Science & Technology (PDS&T) – Biologics organization supports manufacturing, process validation, regulatory submission, and continuous improvement for late‑stage and commercial manufacturing of biological toxin products  have an exciting opportunity for a senior scientist I position based in Irvine, CA. This role involves leveraging scientific and bioengineering principles to develop bioassays for analytical testing at drug substance and drug product release and stability time points.

The candidate must possess in‑depth knowledge and hands‑on experience in a range of techniques, including but not limited to molecular cloning, mammalian cell culture, PCR, Western blot, cell sorting, bioassay, microscopy, transfection, HPLC, and mass spectrometry. Excellent communication skills and ability to thrive in a multi‑disciplinary and cross‑functional team environment are essential for success in this role.

• Lead scientific initiatives by generating innovative technical ideas and strategic approaches to advance research objectives and overcome experimental challenges.
• Align research activities with project goals and adapt experimental plans as needed based on new data and shifting priorities.
• Design, execute, and interpret complex experiments with rigorous methodology to ensure reproducibility and accurate data interpretation.
• Develop and optimize novel experimental protocols leveraging emerging technologies to drive scientific progress and solve technical issues.
• Maintain advanced expertise in relevant scientific and technical disciplines and apply this knowledge to experimental design, troubleshooting, and method development.
• Establish and manage clear experimental timelines and ensure timely completion of project deliverables.
• Deliver high‑quality scientific communication by drafting and editing SOPs, reports, publications, presentations, and patent applications according to industry and regulatory standards.

• Advanced degree in a relevant field:
  Ph.D. (preferably with 6+ months biopharmaceutical industry experience) or Master’s (6+ years industry experience) or Bachelor’s (8+ years industry experience) in Cell and Molecular Biology, Biochemistry, Biotechnology, Biomedical Engineering, or closely related disciplines.
• Robust research background in neuroscience, with experience in neural cancer cell and primary cell culture, 3D cell models, and complex co‑culture systems.
• Proficiency in RNA microinjection, stable cell line generation, and cell‑based assay development.
• Experience with high‑resolution imaging and live‑cell imaging techniques, including advanced confocal microscopy and fluorescence‑based assays.
• Extensive laboratory experience with molecular cloning, mammalian cell culture, PCR, Western blotting, cell sorting, bioassays, advanced microscopy, transfection, HPLC, and mass spectrometry.
• Knowledge of genome editing approaches such as CRISPR/Cas9 and validation of gene editing experiments.
• Previous GxP experience with attention to detail in documentation.
• Strong computer skills, including scientific data analysis (Python, R, JMP) and laboratory automation.
• Demonstrated scientific leadership with published research and patents.
• Ability to keep pace with scientific advances and integrate emerging techniques.
• Detail‑oriented, collaborative, and self‑motivated with a passion for scientific discovery.

• Compensation range is a base pay range that may vary by location and role. Pay may be modified in the future.
• Benefits include paid time off, medical/dental/vision insurance, 401(k) eligibility, and short‑term incentive programs.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer/Veterans/Disabled.