Director, GHER TMTT

Director, GHER TMTT Real World Evidence

Edwards Lifesciences

Innovation starts from the heart. Edwards Lifesciences is the leading global structural heart innovation company, driven by a passion to improve patient lives. With millions of patients served in over 100 countries, each team makes a meaningful contribution by improving patient outcomes and discovering lasting solutions for unmet patient needs. Our Director, GHER TMTT Real World Evidence position is a unique career opportunity that could be your next step towards an exciting future.

This is a compelling opportunity to join the Global Health Economics & Reimbursement (GHER) team at Edwards Lifesciences, supporting patient access to innovative transcatheter mitral and tricuspid valve technologies (TMTT).

As Director of Real‑World Evidence (RWE), you will lead the strategic planning, execution, and oversight of real‑world evidence generation using real‑world data (RWD) to identify patient unmet needs, overcome market‑access barriers, and drive impactful evidence for clinical, regulatory, and commercial success. The role also includes direct people‑leadership responsibilities with a strong emphasis on talent development, team building, and performance management. This hybrid position is based in Irvine, CA, requiring regular in‑office presence, and reports directly to the VP of TMTT GHER.

• Provide leadership, vision, and direction for the RWE team, fostering a collaborative, high‑performance culture.
• Oversee the planning, design, execution, and delivery of multiple, concurrent RWE projects (including studies conducted internally and with external consultants—ensuring scientific rigor and business alignment).
• Serve as a business partner and consultant, collaborating cross‑functionally with colleagues across Edwards Lifesciences to meet organizational objectives.
• Develop and implement evidence‑generation strategies using RWD to articulate value, address unmet needs, and support portfolio planning, commercialization, and patient access.
• Demonstrated success in building and scaling high‑performing teams within Real‑World Evidence or related functions.
• Lead and mentor multidisciplinary teams in developing study designs, endpoint operationalization, and analytic plans for assigned studies.
• Direct the development and execution of data management plans across various relational databases, with proficiency in data cleaning, manipulation, and programming (SQL, R, or Python).
• Guide and collaborate on complex statistical analyses, including longitudinal data analysis, GLM, survival analysis, and propensity score matching.
• Collaborate with internal and external data management and statistical programming teams to generate research datasets and deliver insights.
• Engage and partner with physicians and clinical experts to develop high‑quality clinical papers, abstracts, and presentations, resulting in publications in top‑tier, peer‑reviewed journals.
• Work collaboratively with the TMTT GHER US Coverage & Payment team, and support efforts to expand patient access to TMTT therapies by generating key evidence to support private and public payer coverage decisions.
• Collaborate with internal teams, particularly the TMTT GHER Service Line Value team, to support the development of customer‑facing resources and programs that address the commercial evidence needs.
• Translate analytical findings into strategic recommendations that directly inform business decisions, market‑access strategies, and value propositions.
• Develop compelling narratives and visualizations that connect evidence generation to business objectives, enabling alignment across product development, payer engagement, and policy planning.
• Partner with external experts to augment internal capabilities, streamline study execution, and accelerate delivery of high‑quality real‑world insights.
• Serve as a strategic thought partner by contextualizing outcomes within broader market dynamics and organizational goals.
• Drive the creation of customized reports and data visualizations using tools such as Tableau or Power BI to translate research findings for diverse stakeholders.
• Build and maintain…